• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

构建新型MYC相关ceRNA调控网络以鉴定结肠腺癌的预后生物标志物

Construction of a Novel MYC-Associated ceRNA Regulatory Network to Identify Prognostic Biomarkers in Colon Adenocarcinoma.

作者信息

Xin Rui, Tang Xiao-Mei, Jiang Ying-Jie, Yu Fei, Li Sha, Jia Cheng-You, Wang Gao-Ren, Fu Da, Liu Ji-Bin, Ma Yu-Shui

机构信息

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Institute of Oncology, Affiliated Tumor Hospital of Nantong University, Nantong 226631, Jiangsu, China.

出版信息

J Oncol. 2022 Jul 5;2022:3216285. doi: 10.1155/2022/3216285. eCollection 2022.

DOI:10.1155/2022/3216285
PMID:35847359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9277212/
Abstract

Colorectal cancer (CRC) includes colon adenocarcinoma (COAD) and rectal adenocarcinoma (READ). Competitive endogenous RNA (ceRNA) is crucial for cancer pathogenesis. Abnormal expression of MYC is generally associated with a poor colon adenocarcinoma prognosis. The present study aimed to identify a novel MYC-associated ceRNA regulatory network and identify potential prognostic markers associated with COAD. We obtained the transcriptome sequencing profiles of 462 COAD cases from the TCGA database and analyzed differentially expressed genes (DEGs) in MYC high expression (MYC) and MYC low expression (Myc) tumors. We identified an important lncRNA, LINC00114, which effectively predicts overall survival and plays a protective role in COAD. Moreover, the LINC00114/miR-216a-5p axis was identified as a clinical prognostic model. The predicted target genes of the LINC00114/miR-216a-5p axis include uromodulin Like 1 (UMODL1) and oncoprotein induced transcript 3 (OIT3), which are closely related to the survival and prognosis of COAD patients. In summary, we constructed a novel ceRNA regulatory network and identified potential biomarkers for the targeted therapy and prognosis of COAD.

摘要

结直肠癌（CRC）包括结肠腺癌（COAD）和直肠腺癌（READ）。竞争性内源性RNA（ceRNA）对癌症发病机制至关重要。MYC的异常表达通常与结肠腺癌预后不良相关。本研究旨在识别一个新的与MYC相关的ceRNA调控网络，并确定与COAD相关的潜在预后标志物。我们从TCGA数据库获得了462例COAD病例的转录组测序图谱，并分析了MYC高表达（MYC）和MYC低表达（Myc）肿瘤中的差异表达基因（DEG）。我们鉴定出一个重要的长链非编码RNA，即LINC00114，它能有效预测总生存期，并在COAD中发挥保护作用。此外，LINC00114/miR-216a-5p轴被确定为一种临床预后模型。LINC00114/miR-216a-5p轴的预测靶基因包括尿调节蛋白样1（UMODL1）和癌蛋白诱导转录物3（OIT3），它们与COAD患者的生存和预后密切相关。总之，我们构建了一个新的ceRNA调控网络，并确定了COAD靶向治疗和预后的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/0787e87c1f55/JO2022-3216285.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/074426b7daa0/JO2022-3216285.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/d5439a54cf16/JO2022-3216285.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/e3229c30fc14/JO2022-3216285.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/e9766325e2b9/JO2022-3216285.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/041e13a0aadb/JO2022-3216285.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/cd5d8b55efeb/JO2022-3216285.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/23ee2150dddc/JO2022-3216285.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/92dc86aafa77/JO2022-3216285.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/ad783423252c/JO2022-3216285.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/f7fc5eb6d27b/JO2022-3216285.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/0787e87c1f55/JO2022-3216285.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/074426b7daa0/JO2022-3216285.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/d5439a54cf16/JO2022-3216285.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/e3229c30fc14/JO2022-3216285.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/e9766325e2b9/JO2022-3216285.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/041e13a0aadb/JO2022-3216285.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/cd5d8b55efeb/JO2022-3216285.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/23ee2150dddc/JO2022-3216285.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/92dc86aafa77/JO2022-3216285.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/ad783423252c/JO2022-3216285.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/f7fc5eb6d27b/JO2022-3216285.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0678/9277212/0787e87c1f55/JO2022-3216285.011.jpg

相似文献

1
Construction of a Novel MYC-Associated ceRNA Regulatory Network to Identify Prognostic Biomarkers in Colon Adenocarcinoma.构建新型MYC相关ceRNA调控网络以鉴定结肠腺癌的预后生物标志物
J Oncol. 2022 Jul 5;2022:3216285. doi: 10.1155/2022/3216285. eCollection 2022.
2
Circadian Clock Genes Are Correlated with Prognosis and Immune Cell Infiltration in Colon Adenocarcinoma.昼夜节律钟基因与结肠腺癌的预后和免疫细胞浸润相关。
Comput Math Methods Med. 2022 Jan 25;2022:1709918. doi: 10.1155/2022/1709918. eCollection 2022.
3
Genome Instability and Long Noncoding RNA Reveal Biomarkers for Immunotherapy and Prognosis and Novel Competing Endogenous RNA Mechanism in Colon Adenocarcinoma.基因组不稳定与长链非编码RNA揭示结肠癌免疫治疗和预后生物标志物及新型竞争性内源RNA机制
Front Cell Dev Biol. 2021 Oct 20;9:740455. doi: 10.3389/fcell.2021.740455. eCollection 2021.
4
Analysis of lncRNA-Associated ceRNA Network Reveals Potential lncRNA Biomarkers in Human Colon Adenocarcinoma.长链非编码RNA相关的竞争性内源RNA网络分析揭示了人类结肠腺癌中潜在的长链非编码RNA生物标志物。
Cell Physiol Biochem. 2018;49(5):1778-1791. doi: 10.1159/000493623. Epub 2018 Sep 19.
5
Biomarker Discovery for the Carcinogenic Heterogeneity Between Colon and Rectal Cancers Based on lncRNA-Associated ceRNA Network Analysis.基于lncRNA相关ceRNA网络分析的结直肠癌与直肠癌致癌异质性生物标志物发现
Front Oncol. 2020 Oct 30;10:535985. doi: 10.3389/fonc.2020.535985. eCollection 2020.
6
Integration analysis of long non-coding RNA (lncRNA) role in tumorigenesis of colon adenocarcinoma.长链非编码 RNA（lncRNA）在结肠腺癌发生中的作用的综合分析。
BMC Med Genomics. 2020 Jul 29;13(1):108. doi: 10.1186/s12920-020-00757-2.
7
Establishing a carcinoembryonic antigen-associated competitive endogenous RNA network and forecasting an important regulatory axis in colon adenocarcinoma patients.建立癌胚抗原相关的竞争性内源性RNA网络并预测结肠癌患者的重要调控轴。
J Gastrointest Oncol. 2024 Feb 29;15(1):220-236. doi: 10.21037/jgo-24-43. Epub 2024 Feb 28.
8
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis.结肠癌转移中ceRNA网络的构建与分析及免疫浸润模式
Front Cell Dev Biol. 2020 Aug 4;8:688. doi: 10.3389/fcell.2020.00688. eCollection 2020.
9
A Competing Endogenous RNA Network Reveals Novel Potential lncRNA, miRNA, and mRNA Biomarkers in the Prognosis of Human Colon Adenocarcinoma.竞争性内源性 RNA 网络揭示了人类结肠腺癌预后的新型潜在 lncRNA、miRNA 和 mRNA 生物标志物。
J Surg Res. 2019 Mar;235:22-33. doi: 10.1016/j.jss.2018.09.053. Epub 2018 Oct 23.
10
Multi-Omics Reveal the Immunological Role and the Theragnostic Value of miR-216a/GDF15 Axis in Human Colon Adenocarcinoma.多组学揭示 miR-216a/GDF15 轴在人结肠癌中的免疫作用和治疗诊断价值。
Int J Mol Sci. 2021 Dec 20;22(24):13636. doi: 10.3390/ijms222413636.

本文引用的文献

1
Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma.构建与Myc相关的ceRNA网络揭示肝细胞癌的预后特征。
Mol Ther Nucleic Acids. 2021 May 1;24:1033-1050. doi: 10.1016/j.omtn.2021.04.019. eCollection 2021 Jun 4.
2
Establishment and experimental validation of an immune miRNA signature for assessing prognosis and immune landscape of patients with colorectal cancer.建立并验证免疫 miRNA 标志物用于评估结直肠癌患者的预后和免疫图谱
J Cell Mol Med. 2021 Jul;25(14):6874-6886. doi: 10.1111/jcmm.16696. Epub 2021 Jun 7.
3
Identification of the 3-lncRNA Signature as a Prognostic Biomarker for Colorectal Cancer.
鉴定 3 个长链非编码 RNA 标志物作为结直肠癌的预后生物标志物。
Int J Mol Sci. 2020 Dec 8;21(24):9359. doi: 10.3390/ijms21249359.
4
Pan-cancer landscape of homologous recombination deficiency.泛癌症同源重组缺陷全景图。
Nat Commun. 2020 Nov 4;11(1):5584. doi: 10.1038/s41467-020-19406-4.
5
The effect of miRNA and autophagy on colorectal cancer.miRNA 和自噬对结直肠癌的影响。
Cell Prolif. 2020 Oct;53(10):e12900. doi: 10.1111/cpr.12900. Epub 2020 Sep 10.
6
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis.结肠癌转移中ceRNA网络的构建与分析及免疫浸润模式
Front Cell Dev Biol. 2020 Aug 4;8:688. doi: 10.3389/fcell.2020.00688. eCollection 2020.
7
Bioinformatics Analysis of Prognostic miRNA Signature and Potential Critical Genes in Colon Cancer.结肠癌预后性miRNA特征及潜在关键基因的生物信息学分析
Front Genet. 2020 Jun 9;11:478. doi: 10.3389/fgene.2020.00478. eCollection 2020.
8
Long Non-coding RNA Facilitates Colorectal Cancer Development Through EZH2/DNMT1-Induced miR-133b Suppression.长链非编码RNA通过EZH2/DNMT1诱导的miR-133b抑制促进结直肠癌发展。
Front Oncol. 2019 Dec 17;9:1383. doi: 10.3389/fonc.2019.01383. eCollection 2019.
9
Biological Network Approach for the Identification of Regulatory Long Non-Coding RNAs Associated With Metabolic Efficiency in Cattle.用于鉴定与牛代谢效率相关的调控性长链非编码RNA的生物网络方法
Front Genet. 2019 Nov 22;10:1130. doi: 10.3389/fgene.2019.01130. eCollection 2019.
10
Tumor-Infiltrating Immune Cells Act as a Marker for Prognosis in Colorectal Cancer.肿瘤浸润免疫细胞可作为结直肠癌预后的标志物。
Front Immunol. 2019 Oct 17;10:2368. doi: 10.3389/fimmu.2019.02368. eCollection 2019.