Jiang Tianlin, Wang Jiahua, Li Chao, Cao Guiyun, Wang Xiaohong
School of Medicine, Yangzhou University, Yangzhou 225001, China.
Department of Anesthesia, Affiliated Hospital of Yangzhou University, Yangzhou 225001, China.
Oxid Med Cell Longev. 2022 Jul 8;2022:7494863. doi: 10.1155/2022/7494863. eCollection 2022.
Prohibitins (PHBs) are conserved proteins in eukaryotic cells, which are mainly located in the inner mitochondrial membrane (IMM), cell nucleus, and cell membrane. PHBs play crucial roles in various cellular functions, including the cell cycle regulation, tumor suppression, immunoglobulin M receptor binding, and aging. In addition, recent in vitro and in vivo studies have revealed that PHBs are important in nervous system diseases. PHBs can prevent apoptosis, inflammation, mitochondrial dysfunction, and autophagy in neurological disorders through different molecules and pathways, such as OPA-1, PINK1/Parkin, IL6/STAT3, Tau, NO, LC3, and TDP43. Therefore, PHBs show great promise in the protection of neurological disorders. This review summarizes the relevant studies on the relationship between PHBs and neurological disorders and provides an update on the molecular mechanisms of PHBs in nervous system diseases.
prohibitin蛋白（PHBs）是真核细胞中的保守蛋白，主要位于线粒体内膜（IMM）、细胞核和细胞膜中。PHBs在各种细胞功能中发挥关键作用，包括细胞周期调控、肿瘤抑制、免疫球蛋白M受体结合和衰老。此外，最近的体外和体内研究表明，PHBs在神经系统疾病中也很重要。PHBs可以通过不同的分子和途径，如OPA-1、PINK1/Parkin、IL6/STAT3、Tau、NO、LC3和TDP43，预防神经疾病中的细胞凋亡、炎症、线粒体功能障碍和自噬。因此，PHBs在保护神经疾病方面显示出巨大的潜力。本文综述了关于PHBs与神经疾病关系的相关研究，并提供了PHBs在神经系统疾病中的分子机制的最新进展。
Zotero 插件