Oyang Linda, Li Jian, Jiang Xianjie, Lin Jinguan, Xia Longzheng, Yang Lixia, Tan Shiming, Wu Nayiyuan, Han Yaqian, Yang Yiqing, Luo Xia, Li Jinyun, Liao Qianjin, Shi Yingrui, Zhou Yujuan
Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
Department of Head and Neck Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
Cancer Cell Int. 2022 Nov 8;22(1):343. doi: 10.1186/s12935-022-02765-x.
Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria. In the mitochondria, PHBs stabilize the structure of the mitochondrial membrane and regulate mitochondrial autophagy, mitochondrial dynamics, mitochondrial biogenesis and quality control, and mitochondrial unfolded protein response. PHBs has shown to be associated with many diseases, such as mitochondria diseases, cancers, infectious diseases, and so on. Some molecule targets of PHBs can interfere with the occurrence and development of diseases. Therefore, this review clarifies the functions of PHBs in mitochondria, and provides a summary of the potential values in clinics.
抑制素（PHBs）是一类在进化上高度保守的蛋白质，广泛分布于原核生物和真核生物中。PHBs在细胞生长、增殖或分化中发挥作用，调节代谢和信号通路。在真核生物中，PHBs具有不同的亚细胞定位，但它们主要位于线粒体中。在线粒体中，PHBs稳定线粒体膜的结构，并调节线粒体自噬、线粒体动力学、线粒体生物发生和质量控制以及线粒体未折叠蛋白反应。PHBs已被证明与许多疾病有关，如线粒体疾病、癌症、传染病等。PHBs的一些分子靶点可以干扰疾病的发生和发展。因此，本综述阐明了PHBs在线粒体中的功能，并总结了其在临床上的潜在价值。
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