Mathias Joacy G, Nolan Vikki G, Meadows-Taylor Meghan, Robinson L Ashley, Howell Kristen E, Gurney James G, Hankins Jane S, Wang Winfred C, Estepp Jeremie H, Smeltzer Matthew P
Division of Epidemiology, Biostatistics, and Environmental Health School of Public Health The University of Memphis Memphis Tennessee.
Department of Hematology St. Jude Children's Research Hospital Memphis Tennessee.
EJHaem. 2020 Apr 26;1(1):235-238. doi: 10.1002/jha2.7. eCollection 2020 Jul.
Due to fear of short-term toxicities, there is nonconsensus of hydroxycarbamide dosing strategy (escalated vs fixed-dosing methods), which contributes to its suboptimal use. We performed a meta-analysis to summarize the incidence rates of toxicities associated with both dosing methods. Summarized incidence rates could not be statistically compared between dosing methods due to sparse data. Summarized neutropenia and thrombocytopenia incidence rates were slightly higher when using escalated dosing than with fixed. Summarized reticulocytopenia was comparable. Summarized hepatic and renal toxicities' incidence rates were slightly higher when using fixed doses than with escalated. We recommend diligent and transparent reporting of toxicities.
由于担心短期毒性，羟基脲给药策略（递增给药法与固定剂量给药法）尚无共识，这导致了其使用效果欠佳。我们进行了一项荟萃分析，以总结两种给药方法相关毒性的发生率。由于数据稀少，无法对两种给药方法的汇总发生率进行统计学比较。递增给药时中性粒细胞减少和血小板减少的汇总发生率略高于固定剂量给药。网织红细胞减少的汇总发生率相当。固定剂量给药时肝脏和肾脏毒性的汇总发生率略高于递增给药。我们建议对毒性进行勤勉且透明的报告。
