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患有种植体周围炎的吸烟者和非吸烟者中可溶性尿激酶型纤溶酶原激活物受体和肿瘤坏死因子-α的种植体周围龈沟液水平。

Levels of peri-implant sulcular fluid levels of soluble urokinase plasminogen activator receptor and TNF-α among cigarette smokers and non-smokers with peri-implantitis.

作者信息

Dewan Harisha, Robaian Ali, Divakar Darshan Devang, Hegde Samrat Megaravalli Ramappa, Shankar Shrinidhi Maji, Poojary Bharathi

机构信息

Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Department of Conservative Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.

出版信息

Technol Health Care. 2023;31(1):1-9. doi: 10.3233/THC-213123.

DOI:10.3233/THC-213123

PMID:35848046

Abstract

BACKGROUND

Soluble urokinase plasminogen activator receptor (suPAR) and tumor necrosis factor-alpha (TNF-α) are inflammatory biomarkers. No studies have yet assessed the suPAR levels in relation with TNF-α in the peri-implant sulcular fluid (PISF) among cigarette smokers and non-smokers with peri-implantitis.

OBJECTIVE

The aim was to evaluate PISF levels of suPAR, and TNF-α among cigarette smokers and non-smokers with and without peri-implantitis.

METHODS

Sixty male patients with peri-implantitis were included. There were 20 cigarette smokers and 20 and non-smokers with peri-implantitis (Groups 1 and 2), and 20 non-smokers without peri-implantitis (Group 3). Demographic data and information related to cigarette smoking was recorded. Peri-implant clinicoradiographic parameters (plaque index [PI], gingival index [GI], probing depth [PD] and crestal bone loss [CBL]) were assessed. The PISF samples were collected and levels of suPAR and TNF-α were measured. Sample-size estimation was performed and all parameters were statistically assessed. Level of significance was set at P< 0.05.

RESULTS

Sixty individuals were included in Groups 1, 2 and 3 (20 in each). Peri-implant PI (P< 0.01), PD (P< 0.01) and mesial (P< 0.01) and distal (P< 0.01) CBL were significantly higher in Group 1 than in Groups 2 and 3. The PISF volume (P< 0.01) and suPAR (P< 0.01) and TNF-α levels (P< 0.01) were significantly higher in Groups 1 and 2 than in Group 3. There was no difference in PISF volume and suPAR and TNF-α levels between patients in Groups 1 and 2. In Group 2, there was a statistically significant correlation between peri-implant PD and PISF suPAR and TNF-α levels (P< 0.01). The suPAR and TNF-α levels are expressed in high concentrations in the PISF of smokers and non-smokers with peri-implantitis compared with non-smokers without peri-implantitis.

CONCLUSION

In non-smokers, PISF suPAR and TNF-α levels are correlated with peri-implant PD.

摘要

背景

可溶性尿激酶型纤溶酶原激活物受体（suPAR）和肿瘤坏死因子-α（TNF-α）是炎症生物标志物。目前尚无研究评估种植体周围炎吸烟者和非吸烟者的种植体周围龈沟液（PISF）中suPAR水平与TNF-α的关系。

目的

评估有或无种植体周围炎的吸烟者和非吸烟者的PISF中suPAR和TNF-α水平。

方法

纳入60例男性种植体周围炎患者。其中20例为吸烟的种植体周围炎患者和20例非吸烟的种植体周围炎患者（第1组和第2组），以及20例无种植体周围炎的非吸烟患者（第3组）。记录人口统计学数据和与吸烟相关的信息。评估种植体周围临床影像学参数（菌斑指数[PI]、牙龈指数[GI]、探诊深度[PD]和牙槽嵴骨吸收[CBL]）。收集PISF样本并测量suPAR和TNF-α水平。进行样本量估计并对所有参数进行统计学评估。显著性水平设定为P<0.05。

结果

第1组、第2组和第3组各纳入20例患者，共60例。第1组的种植体周围PI（P<0.01）、PD（P<0.01）以及近中（P<0.01）和远中（P<0.01）CBL显著高于第2组和第3组。第1组和第2组的PISF体积（P<0.01）、suPAR（P<0.01）和TNF-α水平（P<0.01）显著高于第3组。第1组和第2组患者的PISF体积、suPAR和TNF-α水平无差异。在第2组中，种植体周围PD与PISF中suPAR和TNF-α水平之间存在统计学显著相关性（P<0.01）。与无种植体周围炎的非吸烟者相比，有种植体周围炎的吸烟者和非吸烟者的PISF中suPAR和TNF-α水平以高浓度表达。