种植体周围沟液中 galectin-1、可溶性尿激酶型纤溶酶原激活物受体和 IL-1β 水平在种植体周围炎症条件下的变化。
Peri-implant Sulcular Fluid Galectin-1, Soluble Urokinase Plasminogen Activator Receptor and IL-1β Levels under Peri-implant Inflammatory Conditions.
出版信息
Oral Health Prev Dent. 2021 Sep 30;19:503-510. doi: 10.3290/j.ohpd.b2082081.
PURPOSE
Soluble urokinase plasminogen activator receptor (suPAR) and interleukin 1-beta (IL-1β) are inflammatory biomarkers, whereas galectin-1 is an anti-inflammatory cytokine. The relationship between suPAR, galactin-1 and IL-1β levels in peri-implant sulcular fluid (PISF) in relation to dental implants remains unaddressed. The aim was to assess suPAR, galectin-1, and IL-1β levels in PISF under peri-implant inflammatory conditions.
MATERIALS AND METHODS
Demographic data and information related to jaw location and duration of implants in function as well as systemic health was retrieved from patients' dental records. Peri-implant plaque and gingival indices (PI and GI, respectively), probing depth (PD) and crestal bone loss (CBL) were recorded. The PISF was collected and levels of suPAR, galectin-1 and IL-1β were determined using standard techniques. Sample-size estimation and statistical analyses were done. Correlation of suPAR and galectin-1 with IL-1β were assessed via logistic regression. p-values < 0.05 were considered statistically significant.
RESULTS
Seventy-two patients (45 males and 27 females) with peri-implant diseases were included. Thirty-six patients (22 males and 14 females) had peri-implant mucositis; 36 (23 males and 13 females) had healthy peri-implant tissues. The PISF volume was statistically significantly higher among patients with (0.52 ± 0.05 µl) than without peri-implant diseases (0.06 ± 0.01 µl) (p < 0.001). The PISF levels of suPAR (p < 0.01), galectin-1 (p < 0.01) and IL-1β (p < 0.01) were statistically significantly higher among patients with than without peri-implant diseases. In patients with peri-implant mucositis, PISF suPAR (p < 0.001) and galectin-1 (p < 0.001) levels correlated with PISF IL-1β levels. In patients with peri-implant mucositis, increasing peri-implant PD and IL-1β levels directly correlated with increased PISF suPAR (p < 0.001) and galectin-1 (p < 0.05) levels.
CONCLUSION
Increased PISF levels of suPAR, galectin and IL-1β suggest that these proteins possibly contribute towards the pathogenesis of peri-implant inflammation, and are potential biomarkers of peri-implant diseases.
目的
可溶性尿激酶型纤溶酶原激活物受体（suPAR）和白细胞介素 1-β（IL-1β）是炎症生物标志物，而半乳糖凝集素-1 是一种抗炎细胞因子。在与牙种植体相关的情况下，种植体周围龈沟液（PISF）中 suPAR、半乳糖凝集素-1 和 IL-1β水平之间的关系尚未得到解决。本研究旨在评估在种植体周围炎症情况下 PISF 中的 suPAR、半乳糖凝集素-1 和 IL-1β水平。
材料和方法
从患者的牙科记录中检索了与颌骨位置和植入物使用时间以及全身健康相关的人口统计学数据和信息。记录了种植体周围菌斑和牙龈指数（PI 和 GI）、探诊深度（PD）和牙槽骨嵴骨丢失（CBL）。收集种植体周围龈沟液并使用标准技术测定 suPAR、半乳糖凝集素-1 和 IL-1β水平。进行了样本量估计和统计分析。通过逻辑回归评估 suPAR 和半乳糖凝集素-1 与 IL-1β的相关性。p 值 < 0.05 被认为具有统计学意义。
结果
共纳入 72 例（45 名男性和 27 名女性）患有种植体周围疾病的患者。36 例（22 名男性和 14 名女性）患有种植体周围黏膜炎；36 例（23 名男性和 13 名女性）具有健康的种植体周围组织。与无种植体周围疾病的患者相比，患有种植体周围黏膜炎的患者的 PISF 体积（0.52 ± 0.05 µl）明显更高（0.06 ± 0.01 µl）（p < 0.001）。与无种植体周围疾病的患者相比，患有种植体周围黏膜炎的患者的 PISF suPAR（p < 0.01）、半乳糖凝集素-1（p < 0.01）和 IL-1β（p < 0.01）水平明显更高。患有种植体周围黏膜炎的患者中，PISF suPAR（p < 0.001）和半乳糖凝集素-1（p < 0.001）水平与 PISF IL-1β水平呈正相关。在患有种植体周围黏膜炎的患者中，随着种植体周围 PD 和 IL-1β水平的增加，PISF suPAR（p < 0.001）和半乳糖凝集素-1（p < 0.05）水平也直接增加。
结论
PISF 中 suPAR、半乳糖凝集素和 IL-1β水平升高表明这些蛋白可能有助于种植体周围炎症的发病机制，并且是种植体周围疾病的潜在生物标志物。
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