[线粒体功能障碍在脊髓损伤中的作用及其相关治疗进展]
[Advances of the role of mitochondrial dysfunction in the spinal cord injury and its relevant treatments].
作者信息
Miao Xin, Lin Junqing, Zheng Xianyou
机构信息
Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2022 Jul 15;36(7):902-907. doi: 10.7507/1002-1892.202203081.
OBJECTIVE
To review the advances of the role of mitochondrial dysfunction in the spinal cord injury (SCI) and its relevant treatments.
METHODS
Focusing on various mechanisms of mitochondrial dysfunction, recent relevant literature at home and abroad was identified to summarize the therapeutic strategies for SCI.
RESULTS
Mitochondrial dysfunction is mainly manifested in abnormalities in mitochondrial energy metabolism, mitochondrial oxidative stress, mitochondrial-mediated apoptosis, mitophagy, mitochondrial permeability transition, and mitochondrial biogenesis, playing a vital role in the development of SCI. Drug that enhanced mitochondrial function have been proved beneficial for the treatment of SCI.
CONCLUSION
Mitochondrial dysfunction can serve as a potential therapeutic target for SCI, providing ideas and basis for the development of SCI therapeutic candidates in the future.
目的
综述线粒体功能障碍在脊髓损伤（SCI）中的作用及其相关治疗进展。
方法
围绕线粒体功能障碍的各种机制，检索国内外近期相关文献，总结SCI的治疗策略。
结果
线粒体功能障碍主要表现为线粒体能量代谢异常、线粒体氧化应激、线粒体介导的凋亡、线粒体自噬、线粒体通透性转换和线粒体生物发生异常，在SCI的发生发展中起重要作用。已证实增强线粒体功能的药物对SCI治疗有益。
结论
线粒体功能障碍可作为SCI的潜在治疗靶点，为未来开发SCI治疗候选药物提供思路和依据。
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