在烃类中使用TMPMg对官能化芳烃和杂芳烃进行区域选择性镁化反应。
Regioselective magnesiations of functionalized arenes and heteroarenes using TMPMg in hydrocarbons.
作者信息
Hess Andreas, Alandini Nurtalya, Guelen Hasret C, Prohaska Jan P, Knochel Paul
机构信息
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany.
出版信息
Chem Commun (Camb). 2022 Aug 4;58(63):8774-8777. doi: 10.1039/d2cc03856k.
We report the preparation of a new hydrocarbon-soluble magnesium amide TMPMg (TMP = 2,2,6,6-tetramethylpiperidyl). This base showed excellent properties for the regioselective magnesiation of various arenes and heteroarenes bearing ethyl esters and carbamates under very mild reaction conditions. Subsequent trapping with aryl iodides (Negishi cross-coupling) gave access to a range of highly functionalized valuable building blocks.
我们报道了一种新的可溶于烃类的镁酰胺TMPMg（TMP = 2,2,6,6 - 四甲基哌啶基）的制备。该碱在非常温和的反应条件下，对带有乙酯和氨基甲酸酯的各种芳烃和杂芳烃进行区域选择性镁化反应表现出优异的性能。随后用芳基碘化物进行捕获（根岸交叉偶联反应）可得到一系列高度官能化的有价值的结构单元。
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