The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China.
Brief Bioinform. 2022 Jul 18;23(4). doi: 10.1093/bib/bbac291.
Hepatocellular carcinoma (HCC) is one of the most common types of cancers and a global health challenge with a low early diagnosis rate and high mortality. The coagulation cascade plays an important role in the tumor immune microenvironment (TME) of HCC. In this study, based on the coagulation pathways collected from the KEGG database, two coagulation-related subtypes were distinguished in HCC patients. We demonstrated the distinct differences in immune characteristics and prognostic stratification between two coagulation-related subtypes. A coagulation-related risk score prognostic model was developed in the Cancer Genome Atlas (TCGA) cohort for risk stratification and prognosis prediction. The predictive values of the coagulation-related risk score in prognosis and immunotherapy were also verified in the TCGA and International Cancer Genome Consortium cohorts. A nomogram was also established to facilitate the clinical use of this risk score and verified its effectiveness using different approaches. Based on these results, we can conclude that there is an obvious correlation between the coagulation and the TME in HCC, and the risk score could serve as a robust prognostic biomarker, provide therapeutic benefits for chemotherapy and immunotherapy and may be helpful for clinical decision making in HCC patients.
肝细胞癌 (HCC) 是最常见的癌症类型之一，也是一个全球性的健康挑战，其早期诊断率低，死亡率高。凝血级联反应在 HCC 的肿瘤免疫微环境 (TME) 中起着重要作用。在这项研究中，基于从 KEGG 数据库中收集的凝血途径，在 HCC 患者中区分出了两种与凝血相关的亚型。我们证明了两种与凝血相关的亚型之间在免疫特征和预后分层方面存在明显差异。在癌症基因组图谱 (TCGA) 队列中开发了一种与凝血相关的风险评分预后模型，用于风险分层和预后预测。在 TCGA 和国际癌症基因组联盟队列中也验证了凝血相关风险评分在预后和免疫治疗中的预测价值。还建立了一个列线图，以方便临床使用该风险评分，并使用不同方法验证其有效性。基于这些结果，我们可以得出结论，HCC 中的凝血与 TME 之间存在明显的相关性，风险评分可以作为一种强大的预后生物标志物，为化疗和免疫治疗提供治疗益处，并可能有助于 HCC 患者的临床决策。
