Brattig N W, Ortmans H, Wildhirt W, Klinge O, Berg P A
J Hepatol. 1987 Apr;4(2):218-23. doi: 10.1016/s0168-8278(87)80083-1.
In a follow-up study of 3 years' duration, serum inhibitory factors (SIF) were analysed in 23 patients with a protracted course of viral hepatitis B (PVH) and 12 patients with chronic persistent hepatitis (CPH). Four patients showed a progressive course, developing chronic active hepatitis, and one died of liver failure. All 4 patients had high and persisting SIF activity. The other patients were either SIF negative or lost SIF during the observation period. The inhibitory moiety was isolated from an albumin-rich serum fraction, indicating that the factor was of the same nature as previously described in patients with acute viral hepatitis B. SIF was also demonstrated in other viral infections but was absent or of low activity in autoimmune, toxic or nutritive disorders. These results suggest that SIF may act as an immunoregulatory molecule protecting the liver from exaggerated immune response.
在一项为期3年的随访研究中，对23例慢性乙型病毒性肝炎（PVH）病程迁延患者和12例慢性持续性肝炎（CPH）患者的血清抑制因子（SIF）进行了分析。4例患者病情呈进行性发展，发展为慢性活动性肝炎，1例死于肝功能衰竭。所有4例患者的SIF活性均高且持续存在。其他患者在观察期内要么SIF阴性，要么失去SIF。抑制部分从富含白蛋白的血清组分中分离出来，表明该因子与先前在急性乙型病毒性肝炎患者中描述的因子性质相同。SIF在其他病毒感染中也有表现，但在自身免疫性、中毒性或营养性疾病中不存在或活性较低。这些结果表明，SIF可能作为一种免疫调节分子，保护肝脏免受过度免疫反应的影响。
