Berg P A, Brattig N
Leber Magen Darm. 1984 Nov;14(6):261-9.
Sera from patients with acute viral hepatitis were found to inhibit the in vitro proliferation of normal lymphocytes induced by different mitogens and antigens. SIF interfered with the intermediate phase of mitogen induced lymphocyte activation which was defined by protein and RNA synthesis indicating that SIF acts as an antiactivator and may belong to immunoregulatory physiologic serum factors. The active moiety could be separated from immunoglobulins and other proteins by means of gel filtration, anion exchange and affinity chromatography. The major SIF activity always copurified with albumin. Evaluation of SIF in sera from patients with acute and protracted viral hepatitis may be helpful in determining the outcome of hepatitis. Thus, fall of SIF activity during acute viral hepatitis always indicated complete recovery while persistence of SIF correlated with ongoing inflammatory process and persistent viral infection.
研究发现，急性病毒性肝炎患者的血清能够抑制不同丝裂原和抗原诱导的正常淋巴细胞在体外的增殖。血清抑制因子（SIF）干扰了丝裂原诱导的淋巴细胞激活的中间阶段，该阶段由蛋白质和RNA合成来定义，这表明SIF作为一种抗激活剂，可能属于免疫调节生理血清因子。通过凝胶过滤、阴离子交换和亲和层析等方法，可以将活性部分与免疫球蛋白和其他蛋白质分离。主要的SIF活性总是与白蛋白共纯化。评估急性和迁延性病毒性肝炎患者血清中的SIF，可能有助于确定肝炎的转归。因此，急性病毒性肝炎期间SIF活性的下降总是表明完全康复，而SIF的持续存在与持续的炎症过程和持续性病毒感染相关。
