铜催化的烷基（杂）芳烃的C-C键氧化裂解反应：实现直接制备腈类化合物
Copper-Catalyzed Oxidative C-C Bond Cleavage of Alkyl-(Hetero)arenes Enabling Direct Access to Nitriles.
作者信息
Xue Gaijun, Xie Fukai, Liang Hongliang, Chen Guoliang, Dai Wen
机构信息
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
出版信息
Org Lett. 2022 Aug 5;24(30):5590-5595. doi: 10.1021/acs.orglett.2c02238. Epub 2022 Jul 18.
The cleavage and functionalization of C-C bonds has emerged as a powerful tool for discovery of new transformations. Herein, we report a protocol that enables direct synthesis of nitriles via copper-catalyzed oxidative cleavage and cyanation of C-C bonds in a wide variety of multicarbon alkyl-substituted (hetero)arenes. Detailed mechanistic studies reveal that a tandem oxidative process is involved in this transformation.
碳-碳键的裂解和官能团化已成为发现新转化反应的有力工具。在此，我们报道了一种方法，该方法能够通过铜催化的多种多碳烷基取代（杂）芳烃中碳-碳键的氧化裂解和氰化反应直接合成腈类化合物。详细的机理研究表明，该转化过程涉及一个串联氧化过程。
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