McGill University Faculty of Medicine and Health Sciences.
Centre for Addiction and Mental Health (CAMH), Toronto, Canada.
Psychiatry Res. 2022 Sep;315:114689. doi: 10.1016/j.psychres.2022.114689. Epub 2022 Jun 23.
Bipolar disorder (BD) and schizophrenia (SCZ) are debilitating disorders that are associated with significant burden and reduced quality of life. In this study, we leveraged microarray data derived from both the Illumina HumanMethylation450 platform to investigate the epigenetic age of individuals with SCZ (n = 40), BD (n = 40), and healthy controls (n = 38), across five epigenetic clocks. Various statistical metrics were used to identify discrepancies between epigenetic and chronological age across the three groups. We observed a significant increase in epigenetic age compared to chronological age in the BD group. Mean epigenetic age acceleration was also higher in individuals with bipolar disorder compared to healthy controls across four different epigenetic clocks (p<0.05). Despite the study's relatively small sample size, these findings suggest that both individuals with bipolar disorder and schizophrenia may have epigenetic markers associated with a premature aging phenotype, which could be suggestive of negative outcomes associated with the disease. In our future studies, we hope to elucidate this finding further by elucidating the precise link between epigenetic age, symptomatology and disease progression.
双相情感障碍（BD）和精神分裂症（SCZ）是使人衰弱的疾病，它们与巨大的负担和生活质量下降有关。在这项研究中，我们利用了 Illumina HumanMethylation450 平台的微阵列数据，从五个表观遗传钟中研究了精神分裂症（n=40）、双相情感障碍（n=40）和健康对照组（n=38）个体的表观遗传年龄。使用各种统计指标来识别三组之间表观遗传年龄和实际年龄之间的差异。我们观察到与实际年龄相比，BD 组的表观遗传年龄明显增加。在四个不同的表观遗传钟中，与健康对照组相比，患有双相情感障碍的个体的平均表观遗传年龄加速也更高（p<0.05）。尽管该研究的样本量相对较小，但这些发现表明，双相情感障碍和精神分裂症患者都可能存在与过早衰老表型相关的表观遗传标志物，这可能表明与疾病相关的负面结果。在我们的未来研究中，我们希望通过阐明表观遗传年龄、症状和疾病进展之间的精确联系，进一步阐明这一发现。
