CAMH, 250 College St, Toronto, M5T1R8, Canada.
St. Michael's Hospital, Toronto, Canada.
Eur Arch Psychiatry Clin Neurosci. 2024 Aug;274(5):1025-1036. doi: 10.1007/s00406-023-01622-w. Epub 2023 Jul 8.
Schizophrenia (SCZ) is a severe psychotic disorder associated with premature mortality and aging. Moreover, the symptoms and progression of psychiatric disorders in general are associated with decreased lifespan, biological aging, and poorer medical outcomes. In this study, we investigated the relationship between several epigenetic clocks and scanned the entire genome for association in a cohort of SCZ individuals (n = 107). Biological age was computed from blood DNA methylation (DNAm) and tested for association against common variants across the genome using general linear models. Genes affecting epigenetic age acceleration in our cohort were found mainly when using the telomeric length clock rather than the other biological clocks. These findings pair with existing evidence that there are some genes associated with longevity and suggest further investigations of putative biological mechanisms for morbidity and premature mortality, not only in patients with SCZ but also in the general population.
精神分裂症（SCZ）是一种严重的精神疾病，与过早死亡和衰老有关。此外，一般精神疾病的症状和进展与寿命缩短、生物衰老和较差的医疗结果有关。在这项研究中，我们调查了几种表观遗传钟与在 SCZ 个体队列（n=107）中进行全基因组关联扫描之间的关系。通过使用广义线性模型，从血液 DNA 甲基化（DNAm）中计算出生物年龄，并针对全基因组中的常见变体进行关联测试。当使用端粒长度时钟而不是其他生物钟时，我们在队列中发现了主要影响表观遗传年龄加速的基因。这些发现与现有的一些与长寿相关的基因的证据相吻合，并建议进一步研究发病率和过早死亡的潜在生物学机制，不仅在 SCZ 患者中，而且在一般人群中。
