Department of NanoEngineering, University of California-San Diego, La Jolla, California, USA.
Center for Nano-ImmunoEngineering, University of California-San Diego, La Jolla, California, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 Jan;15(1):e1832. doi: 10.1002/wnan.1832. Epub 2022 Jul 18.
Single dose slow-release vaccines herald a new era in vaccine administration. An ideal device for slow-release vaccine delivery would be minimally invasive and self-administered, making these approaches an attractive alternative for mass vaccination programs, particularly during the time of a pandemic. In this review article, we discuss the latest advances in this field, specifically for prophylactic vaccines able to prevent infectious diseases. Recent studies have found that slow-release vaccines elicit better immune responses and often do not require cold chain transportation and storage, thus drastically reducing the cost, streamlining distribution, and improving efficacy. This promise has attracted significant attention, especially when poor patient compliance of the standard multidose vaccine regimes is considered. Single dose slow-release vaccines are the next generation of vaccine tools that could overcome most of the shortcomings of present vaccination programs and be the next platform technology to combat future pandemics. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanomaterials and Implants Biology-Inspired Nanomaterials > Protein and Virus-Based Structures.
单剂长效疫苗预示着疫苗接种新时代的到来。理想的长效疫苗输送装置应该微创且可自我给药，这使得这些方法成为大规模疫苗接种计划的一种有吸引力的选择，尤其是在大流行期间。在这篇综述文章中，我们讨论了该领域的最新进展，特别是针对能够预防传染病的预防性疫苗。最近的研究发现，长效疫苗可引发更好的免疫反应，而且通常不需要冷链运输和储存，从而大大降低了成本，简化了分配，并提高了疗效。考虑到标准多剂量疫苗方案的患者顺应性差，这一前景引起了广泛关注。单剂长效疫苗是下一代疫苗工具，它可以克服目前疫苗接种计划的大部分缺点，并成为对抗未来大流行的下一个平台技术。本文属于以下类别： 治疗方法和药物发现 > 新兴技术 可植入材料和手术技术 > 纳米材料和植入物 仿生纳米材料 > 基于蛋白质和病毒的结构。
