Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, China.
Institute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs, Beijing, China.
Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166495. doi: 10.1016/j.bbadis.2022.166495. Epub 2022 Jul 16.
Cell polarity refers to the uneven distribution of certain cytoplasmic components in a cell with a spatial order. The planar cell polarity (PCP), the cell aligns perpendicular to the polar plane, in endothelial cells (ECs) has become a research hot spot. The planar polarity of ECs has a positive significance on the regulation of cardiovascular dysfunction, pathological angiogenesis, and ischemic stroke. The endothelial polarity is stimulated and regulated by biomechanical force. Mechanical stimuli promote endothelial polarization and make ECs produce PCP to maintain the normal physiological and biochemical functions. Here, we overview recent advances in understanding the interplay and mechanism between PCP and ECs function involved in mechanical forces, with a focus on PCP signaling pathways and organelles in regulating the polarity of ECs. And then showed the related diseases caused by ECs polarity dysfunction. This study provides new ideas and therapeutic targets for the treatment of endothelial PCP-related diseases.
细胞极性是指细胞内某些细胞质成分在空间上呈现不均匀分布的状态。平面细胞极性（PCP）是指细胞沿极性平面排列垂直，在血管内皮细胞（ECs）中已成为研究热点。ECs 的平面极性对心血管功能障碍、病理性血管生成和缺血性中风的调节具有积极意义。内皮极性受到生物力学力的刺激和调节。机械刺激促进内皮极化，使 ECs 产生 PCP，以维持正常的生理和生化功能。在这里，我们综述了近年来对机械力作用下 PCP 与 ECs 功能相互作用和机制的理解进展，重点介绍了 PCP 信号通路和细胞器在调节 ECs 极性中的作用。然后展示了由 ECs 极性功能障碍引起的相关疾病。这项研究为治疗内皮 PCP 相关疾病提供了新的思路和治疗靶点。
