Nanchang University, Nanchang City 343000, Jiangxi Province, China.
Emergency Department, The Second Affiliated Hospital, Nanchang University, Nanchang City 343000, Jiangxi Province, China.
Brain Res Bull. 2022 Sep;187:199-209. doi: 10.1016/j.brainresbull.2022.07.006. Epub 2022 Jul 15.
Different studies have confirmed P2X7 receptor-mediated inflammatory mediators play a key role in the development of pain. P2X7 receptor activation can induce the development of pain by mediating the release of inflammatory mediators. In view of the fact that P2X7 receptor is expressed in the nervous system and immune system, it is closely related to the stability and maintenance of the nervous system function. ATP activates P2X7 receptor, opens non-selective cation channels, activates multiple intracellular signaling, releases multiple inflammatory cytokines, and induces pain. At present, the role of P2X7 receptor in inflammatory response and pain has been widely recognized and affirmed. Therefore, in this paper, we discussed the pathological mechanism of P2X7 receptor-mediated inflammation and pain, focused on the internal relationship between P2X7 receptor and pain. Moreover, we also described the effects of some antagonists on pain relief by inhibiting the activities of P2X7 receptor. Thus, targeting to inhibit activation of P2X7 receptor is expected to become another potential target for the relief of pain.
不同的研究已经证实，P2X7 受体介导的炎症介质在疼痛的发展中起着关键作用。P2X7 受体的激活可以通过介导炎症介质的释放来诱导疼痛的发展。鉴于 P2X7 受体在神经系统和免疫系统中表达，它与神经系统功能的稳定性和维持密切相关。ATP 激活 P2X7 受体，打开非选择性阳离子通道，激活多种细胞内信号转导，释放多种炎症细胞因子，并引起疼痛。目前，P2X7 受体在炎症反应和疼痛中的作用已得到广泛认可和肯定。因此，本文讨论了 P2X7 受体介导的炎症和疼痛的病理机制，重点关注了 P2X7 受体与疼痛之间的内在关系。此外，我们还描述了一些拮抗剂通过抑制 P2X7 受体的活性对缓解疼痛的作用。因此，靶向抑制 P2X7 受体的激活有望成为缓解疼痛的另一个潜在靶点。
