Department of Cardiology, Liangzhu Hospital, Yuhang District, Hangzhou, Zhejiang, China.
Department of Cardiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
J Int Med Res. 2022 Jul;50(7):3000605221109387. doi: 10.1177/03000605221109387.
To explore the influence of apolipoprotein E () genotypes and blood lipid metabolism on coronary artery disease (CAD) with atrial fibrillation (AF).
Patients with suspected CAD were consecutively enrolled and divided into groups with or without CAD and/or AF. Blood lipid levels and genotypes were determined and analysed for associations with CAD and AF.
A total of 2048 patients were included (400 patients without CAD or AF [controls], 126 patients without CAD but with AF, 1294 patients with CAD without AF, and 228 patients with CAD and AF). Age and lipoprotein (a) (Lp[a]) levels were significantly higher in patients with CAD and AF versus those with CAD without AF. Among patients with CAD, the E3/E3 genotype and ε3 allele frequencies were significantly lower in patients with AF than in those without AF, and the E4/E4 genotype and ε4 allele frequencies were significantly increased. Multivariate logistic regression revealed that increased Lp(a) levels and age were independent risk factors for AF in patients with CAD.
Among patients with CAD, those with AF had increased age, ε4 frequencies and Lp(a) levels. Age and Lp(a) levels may be independent risk factors for AF in patients with CAD.
探讨载脂蛋白 E () 基因型和血脂代谢对合并心房颤动 (AF) 的冠心病 (CAD) 的影响。
连续纳入疑似 CAD 患者，并分为 CAD 合并 AF 组、CAD 不合并 AF 组、AF 不合并 CAD 组和 CAD 不合并 AF 组。检测血脂水平和 基因型，并分析其与 CAD 和 AF 的相关性。
共纳入 2048 例患者（400 例无 CAD 或 AF [对照组]、126 例无 CAD 但有 AF、1294 例有 CAD 但无 AF、228 例有 CAD 合并 AF）。与 CAD 不合并 AF 组相比，CAD 合并 AF 组患者的年龄和脂蛋白 (a)（Lp[a]）水平明显更高。在 CAD 患者中，与无 AF 患者相比，AF 患者的 E3/E3 基因型和 ε3 等位基因频率明显降低，E4/E4 基因型和 ε4 等位基因频率明显升高。多变量 logistic 回归显示，Lp(a)水平升高和年龄增加是 CAD 患者 AF 的独立危险因素。
在 CAD 患者中，AF 患者的年龄、ε4 频率和 Lp(a)水平增加。年龄和 Lp(a)水平可能是 CAD 患者 AF 的独立危险因素。
