Luo Danyang, Jiang Liting, Gao Yiming
Department of Stomatology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University; College of Stomatology, Shanghai Jiao Tong University, Shanghai 200025, China.
Department of Stomatology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University; College of Stomatology, Shanghai Jiao Tong University, Shanghai 200025, China. *Corresponding author, E-mail:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2022 Aug;38(8):754-759.
T follicular helper (Tfh) cells, one of the subsets of CD4 T cells, play a crucial role in follicles of secondary lymphoid organs. Mature Tfh cells promote the differentiation of B cells into long-lived plasma cells and facilitate immunoglobulin class switch recombination. Recent studies have shown that patients with Sjogren's Syndrome have an increased frequency of Tfh cells in the blood and salivary glands, which are related to the course and severity of the disease. We provides an overview of the differentiation process of Tfh cells, with an emphasis on the distribution, mechanism of action and potential therapeutic importance of Tfh cells in Sjogren's syndrome.
滤泡辅助性T（Tfh）细胞是CD4 T细胞的一个亚群，在次级淋巴器官的滤泡中发挥关键作用。成熟的Tfh细胞促进B细胞分化为长寿浆细胞，并促进免疫球蛋白类别转换重组。最近的研究表明，干燥综合征患者血液和唾液腺中Tfh细胞的频率增加，这与疾病的进程和严重程度相关。我们概述了Tfh细胞的分化过程，重点介绍了Tfh细胞在干燥综合征中的分布、作用机制和潜在治疗重要性。
