Medical University of Pleven, Pleven, Bulgaria.
Folia Med (Plovdiv). 2021 Aug 31;63(4):519-526. doi: 10.3897/folmed.63.e60249.
Collagen type I is a major structural component of human uterus. Recent studies have found that collagen type I turnover is altered in preeclampsia and imbalance occurs between collagen synthesis and degradation processes. This acts as a stimulus for abnormal changes in the concentrations of collagen type I derived products in circulating blood.
Having in mind the pathological collagen type I turnover in preeclampisa, the aim of the present study was to determine the levels of N-terminal propeptide of collagen type I (PINP), C-terminal propeptide of collagen type I (PICP): both markers of collagen type I synthesis and levels of matrix metalloproteinase-1 (MMP-1): marker of collagen type I degradation in sera of women with early-onset preeclampsia.
Thirty-two patients with early-onset preeclampsia were examined. The mean age of the patients was 28.8±5.5 years; and the mean age of 22 age-matched healthy pregnant women was 28.5±6.0 years. The enzyme-linked immunosorbent assay (ELISA) was used for measuring serum levels of PINP, PICP and MMP-1.
There were no statistically significant differences between levels of PINP, PICP and MMP-1 in the sera of women with preeclampsia and healthy pregnancies: 16.991 (15.41÷21.143) vs. 17.189 (15.805÷20.747) µg/L (KW=0.02; p>0.05), 10.929 (8.7÷13.937) vs. 11.474 (7.369÷11.932) µg/L (KW=0.026; p>0.05), and 2.097 (1.384÷2.923) vs. 2.589 (1.41÷4.533) µg/L (KW=0.238; p>0.05), respectively. There were statistically significantly higher number of patients from the preeclampsia group than healthy pregnant women with BMI≥25 (23/32 vs. 4/22) and abnormal UAD (18/32 vs. 2/22) (p.
胶原蛋白 I 型是人体子宫的主要结构成分。最近的研究发现，子痫前期中胶原蛋白 I 型的转化发生改变，并且胶原蛋白的合成和降解过程之间发生失衡。这会刺激循环血液中胶原蛋白 I 衍生产物浓度发生异常变化。
鉴于子痫前期中病理性的胶原蛋白 I 型转化，本研究旨在确定 N 端前肽的胶原蛋白 I 型（PINP）、C 端前肽的胶原蛋白 I 型（PICP）：两者均为胶原蛋白 I 合成的标志物，以及基质金属蛋白酶-1（MMP-1）：胶原蛋白 I 降解的标志物在早发型子痫前期妇女血清中的水平。
检查了 32 例早发型子痫前期患者。患者的平均年龄为 28.8±5.5 岁；22 名年龄匹配的健康孕妇的平均年龄为 28.5±6.0 岁。使用酶联免疫吸附测定（ELISA）法测量血清中 PINP、PICP 和 MMP-1 的水平。
子痫前期和健康妊娠妇女血清中 PINP、PICP 和 MMP-1 的水平无统计学差异：16.991（15.41÷21.143）vs. 17.189（15.805÷20.747）µg/L（KW=0.02；p＞0.05），10.929（8.7÷13.937）vs. 11.474（7.369÷11.932）µg/L（KW=0.026；p＞0.05），和 2.097（1.384÷2.923）vs. 2.589（1.41÷4.533）µg/L（KW=0.238；p＞0.05）。子痫前期组中 BMI≥25（23/32 比 4/22）和 UAD 异常（18/32 比 2/22）的患者数量明显多于健康孕妇（p<0.05）。
