Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Department of Biology, Washington University in St. Louis, St Louis, MO 63130, USA; Center for Science & Engineering of Living Systems (CSELS), McKelvey School of Engineering, Washington University in St Louis, St Louis, MO 63130, USA.
Trends Cell Biol. 2022 Nov;32(11):908-919. doi: 10.1016/j.tcb.2022.06.008. Epub 2022 Jul 15.
Pioneering work carried out over 60 years ago discovered that bacterial cell size is proportional to the growth rate set by nutrient availability. This relationship is traditionally referred to as the 'growth law'. Subsequent studies revealed the growth law to hold across all orders of life, a remarkable degree of conservation. However, recent work suggests the relationship between growth rate, nutrients, and cell size is far more complicated and less deterministic than originally thought. Focusing on bacteria and yeast, here we review efforts to understand the molecular mechanisms underlying the relationship between growth rate and cell size.
60 多年前的开创性工作发现，细菌细胞大小与营养物质可用性设定的生长速率成正比。这种关系传统上被称为“生长律”。随后的研究表明，生长律在所有生命秩序中都成立，具有显著的保守性。然而，最近的研究表明，生长速率、营养物质和细胞大小之间的关系比最初想象的要复杂得多，也不那么确定。本文以细菌和酵母为重点，综述了人们为理解生长速率和细胞大小之间关系的分子机制所做的努力。
