Vadia Stephen, Levin Petra Anne
Department of Biology, Washington University in Saint Louis, Saint Louis, MO 63130, United States.
Department of Biology, Washington University in Saint Louis, Saint Louis, MO 63130, United States.
Curr Opin Microbiol. 2015 Apr;24:96-103. doi: 10.1016/j.mib.2015.01.011. Epub 2015 Feb 5.
Research into the mechanisms regulating bacterial cell size has its origins in a single paper published over 50 years ago. In it Schaechter and colleagues made the observation that the chemical composition and size of a bacterial cell is a function of growth rate, independent of the medium used to achieve that growth rate, a finding that is colloquially referred to as 'the growth law'. Recent findings hint at unforeseen complexity in the growth law, and suggest that nutrients rather than growth rate are the primary arbiter of size. The emerging picture suggests that size is a complex, multifactorial phenomenon mediated through the varied impacts of central carbon metabolism on cell cycle progression and biosynthetic capacity.
对细菌细胞大小调控机制的研究起源于50多年前发表的一篇论文。在该论文中，谢克特及其同事观察到细菌细胞的化学组成和大小是生长速率的函数，与实现该生长速率所使用的培养基无关，这一发现通俗地称为“生长定律”。最近的研究结果暗示了生长定律中存在不可预见的复杂性，并表明营养物质而非生长速率是大小的主要决定因素。新出现的情况表明，大小是一种复杂的多因素现象，是通过中心碳代谢对细胞周期进程和生物合成能力的不同影响来介导的。
