Key Laboratory for Micro-Nano Materials for Energy Storage and Conversion of Henan Province, College of Chemical and Materials Engineering, Institute of Surface Micro and Nano Materials, Xuchang University, Xuchang, Henan 461000, P. R. China.
School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, P. R. China.
Dalton Trans. 2022 Aug 9;51(31):11693-11702. doi: 10.1039/d2dt01696f.
Nanozymes show great promise in bioanalysis and therapeutics, which largely rely on high catalytic efficiency and selectivity. Inspired by the interfacial electronic interaction between noble metals and transition metal carbides, Pt nanozymes are modified with TiC MXene nanosheets to construct TiC/Pt hybrids with synergistically enhanced catalytic activity. Although TiC does not have oxidase and peroxidase-like activity, it can greatly selectively enhance the peroxidase-like activity of Pt nanozymes. Near-infrared irradiation can further increase specifically the peroxidase-like activity of TiC/Pt. The optimal peroxidase-like activity of TiC/Pt is 6 times higher than Pt in the dark and 7.9 times higher than Pt under illumination. This catalytic enhancement is attributed to the interplay of the strong interfacial electron effect and unique photothermal effect of TiC. Using the superior peroxidase-like activity of TiC/Pt, dual mechanism colorimetric methods based on cascade reaction and inhibitory effect are developed for specific detection of glucose and glutathione with a limit of detection of 1.0 μM and 0.0089 μM, respectively. Our work provides an effective means to improve the catalytic activity and selectivity of nanozymes by introduction of an ideal supporter, which will be of value for the design of efficient nanozymes.
纳米酶在生物分析和治疗中具有广阔的应用前景，这主要依赖于其高催化效率和选择性。受贵金属与过渡金属碳化物界面电子相互作用的启发，我们采用 TiC MXene 纳米片对 Pt 纳米酶进行修饰，构建了具有协同增强催化活性的 TiC/Pt 杂化材料。虽然 TiC 本身不具有氧化酶和过氧化物酶样活性，但它可以极大地选择性增强 Pt 纳米酶的过氧化物酶样活性。近红外辐射可以进一步特异性地增加 TiC/Pt 的过氧化物酶样活性。在黑暗中，TiC/Pt 的过氧化物酶样活性最佳，比 Pt 高 6 倍；在光照下，TiC/Pt 的过氧化物酶样活性比 Pt 高 7.9 倍。这种催化增强归因于 TiC 强界面电子效应和独特的光热效应的相互作用。利用 TiC/Pt 的优越过氧化物酶样活性，我们开发了基于级联反应和抑制效应的双机制比色法，分别用于葡萄糖和谷胱甘肽的特异性检测，检测限分别为 1.0 μM 和 0.0089 μM。我们的工作为通过引入理想的载体来提高纳米酶的催化活性和选择性提供了一种有效手段，这对于设计高效纳米酶具有重要价值。
