用于测定呼出气冷凝物中氯氮卓的纳米复合水凝胶催化的HO/TMB体系的开发。

Development of a nanocomposite hydrogel catalyzed HO/TMB system for determination of chlordiazepoxide in exhaled breath condensate.

作者信息

Sefid-Sefidehkhan Yasaman, Karimzadeh Zahra, Jouyban Abolghasem, Khoubnasabjafari Maryam, Jouyban-Gharamaleki Vahid, Rahimpour Elaheh

机构信息

Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences Tabriz Iran

Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences Tabriz Iran.

出版信息

RSC Adv. 2024 Sep 13;14(40):29143-29150. doi: 10.1039/d4ra03751k. eCollection 2024 Sep 12.

In this study, an enzyme mimic catalyzed HO-tetramethylbenzidine system based on UiO-66/Au NPs-PVA nanocomposite hydrogel was employed as an optical probe for chlordiazepoxide sensing. An excellent detection limit of 0.0032 μg mL with a linear range of 0.005-2.0 μg mL was obtained for chlordiazepoxide in exhaled breath condensate samples under optimal conditions. The validated system showed good repeatability, simplicity, and stability toward chlordiazepoxide sensing in the exhaled breath condensate of patients receiving this drug.