Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Solna, Sweden.
SWEAH, Department of Health Sciences, Lund University, Lund, Sweden.
Aging (Albany NY). 2022 Jul 18;14(15):5984-6005. doi: 10.18632/aging.204182.
Successful aging is a multidimensional construct covering behavioral, social, and psychological domains of well-being. We aimed to identify well-being profiles and their association with mobility-limitation-free survival.
A total of 1488 healthy individuals aged 60+ from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) were followed-up for 15 years. Mobility limitation was defined as a walking speed <0.8m/s and vital status information was obtained from the National Cause of Death Register. Well-being profiles were derived from different behavioral, social and psychological indicators using latent class analysis among men and women. Cox and Laplace regression models were applied to examine the association with the incidence of a composite endpoint of mobility limitation or death.
At baseline, three well-being profiles (i.e., worst, intermediate, best) were identified, which followed a clear gradient in all behavioral, social and psychological indicators. Compared to those in the worst profile, men and women in the intermediate profile had 27% (HR 0.73; 95% CI 0.56-0.94) and 23% (HR 0.77; 95% CI 0.59-1.00) lower hazard of developing mobility limitation/death. An even greater protective effect was seen among individuals in the best versus worst profile (HR 0.47; 95% CI 0.31-0.70 in men; HR 0.60; 95% CI 0.46-0.78 in women). Men in the intermediate and best profiles survived 1 and 3 years longer without mobility limitation, respectively; these figures were 2 and 3 years for women.
Better profiles of behavioral, social and psychological well-being may prolong mobility-limitation-free survival by at least one year among older adults. Our findings strengthen the evidence-base to achieve successful aging through multi-domain interventions.
成功老龄化是一个多维结构，涵盖行为、社会和心理福祉领域。我们旨在确定福祉状况，并研究其与无行动受限生存的关系。
共有 1488 名年龄在 60 岁以上的来自瑞典 Kungsholmen 老龄化和护理全国研究（SNAC-K）的健康个体参与了本研究，随访时间为 15 年。行动受限的定义为行走速度＜0.8m/s，生存状态信息来自全国死因登记处。使用潜在类别分析，从不同的行为、社会和心理指标中，对男性和女性的福祉状况进行了分类。应用 Cox 和 Laplace 回归模型来检验与行动受限或死亡这一复合终点的发生风险的相关性。
在基线时，确定了三种福祉状况（即最差、中等和最佳），它们在所有行为、社会和心理指标上都呈现出明显的梯度。与最差状况的个体相比，中等状况的男性和女性发生行动受限/死亡的风险分别降低了 27%（HR 0.73；95%CI 0.56-0.94）和 23%（HR 0.77；95%CI 0.59-1.00）。在最佳状况的个体中，这一保护作用更为显著（男性 HR 0.47；95%CI 0.31-0.70；女性 HR 0.60；95%CI 0.46-0.78）。与最差状况的个体相比，处于中等和最佳状况的男性分别多存活 1 年和 3 年而无行动受限，女性则分别多存活 2 年和 3 年。
行为、社会和心理福祉状况更好的个体，其无行动受限的生存时间至少延长 1 年。我们的研究结果进一步证实了通过多领域干预来实现成功老龄化的证据基础。
