Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
STAR Protoc. 2022 Sep 16;3(3):101564. doi: 10.1016/j.xpro.2022.101564. Epub 2022 Jul 18.
The cleavage and functionalization of carbon-carbon (C-C) bonds has emerged as a powerful tool for preparing value-added chemicals. In this protocol, we describe the preparation of amorphous manganese oxide and its application as a heterogeneous catalyst in the direct synthesis of amides via successive cleavage and amidation of C-C bonds in alcohols. Furthermore, we describe how a slight modification of reaction conditions allows for the cleavage and cyanation of alcohols to access sterically hindered nitriles. For complete details on the use and execution of this protocol, please refer to He et al. (2022).
碳-碳（C-C）键的断裂和功能化已成为制备高附加值化学品的有力工具。在本方案中，我们描述了非晶态氧化锰的制备及其作为多相催化剂在醇中通过 C-C 键的连续断裂和酰胺化反应直接合成酰胺中的应用。此外，我们还描述了如何通过略微修改反应条件来实现醇的断裂和氰化，以获得位阻腈。有关此方案使用和执行的完整详细信息，请参阅 He 等人（2022 年）。
