Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China.
Shanghai Dermatology Hospital, Shanghai 200443, China.
Drug Discov Today. 2020 May;25(5):901-908. doi: 10.1016/j.drudis.2019.09.018. Epub 2019 Oct 5.
Beyond their traditional use as green solvents, new applications have become available for ionic liquids (ILs) in drug delivery. Their flexible tunability enables task-specific optimization of ILs at molecular level. Thus, ILs have been exploited to improve the solubility and permeability of drugs and relieve the polymorphic problems associated with crystalline active pharmaceutical ingredients (APIs). Controlled preparation of drug nanocarriers are also achieved by using ILs either as media or as functional agents. Here, we highlight the importance and advantages of ILs in pharmaceutics and look towards the future of IL-based drug delivery.
除了作为绿色溶剂的传统用途外，离子液体（ILs）在药物传递方面也有了新的应用。它们具有灵活的可调性，可以在分子水平上对 ILs 进行特定任务的优化。因此，ILs 已被用于提高药物的溶解度和渗透性，并缓解与结晶活性药物成分（APIs）相关的多晶型问题。通过使用 ILs 作为介质或功能剂，还可以实现药物纳米载体的控制制备。在这里，我们强调了 ILs 在药剂学中的重要性和优势，并展望了基于 IL 的药物传递的未来。
