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无电池柔性无线血糖监测系统。

Flexible battery-less wireless glucose monitoring system.

机构信息

Center for Bioelectronics, Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, 23528, USA.

出版信息

Sci Rep. 2022 Jul 19;12(1):12356. doi: 10.1038/s41598-022-16714-1.

Abstract

In this work, a low power microcontroller-based near field communication (NFC) interfaced with a flexible abiotic glucose hybrid fuel cell is designed to function as a battery-less glucose sensor. The abiotic glucose fuel cell is fabricated by depositing colloidal platinum (co-Pt) on the anodic region and silver oxide nanoparticles-multiwalled carbon nanotubes (AgO-MWCNTs) composite on the cathodic region. The electrochemical behavior is characterized using cyclic voltammetry and chronoamperometry. This glucose hybrid fuel cell generated an open circuit voltage of 0.46 V, short circuit current density of 0.444 mA/cm, and maximum power density of 0.062 mW/cm at 0.26 V in the presence of 7 mM physiologic glucose. Upon device integration of the abiotic glucose hybrid fuel cell with the NFC module, the data from the glucose monitoring system is successfully transmitted to an android application for visualization at the user interface. The cell voltage correlated (r = 0.989) with glucose concentration (up to 19 mM) with a sensitivity of 13.9 mV/mM•cm.

摘要

在这项工作中,设计了一种基于低功耗微控制器的近场通信(NFC)接口与柔性非生物葡萄糖混合燃料电池,用作无电池葡萄糖传感器。非生物葡萄糖燃料电池通过在阳极区域沉积胶体铂(co-Pt)和在阴极区域沉积氧化银纳米颗粒-多壁碳纳米管(AgO-MWCNTs)复合材料来制备。使用循环伏安法和计时安培法对其电化学行为进行了表征。在存在 7mM 生理葡萄糖的情况下,该葡萄糖混合燃料电池在 0.26V 时产生 0.46V 的开路电压、0.444mA/cm 的短路电流密度和 0.062mW/cm 的最大功率密度。在将非生物葡萄糖混合燃料电池与 NFC 模块进行设备集成后,成功地将葡萄糖监测系统的数据传输到安卓应用程序,在用户界面上进行可视化。电池电压与葡萄糖浓度呈相关性(r=0.989),可达 19mM,灵敏度为 13.9mV/mM·cm。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa04/9296503/381b6a1a7c7b/41598_2022_16714_Fig1_HTML.jpg

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