Dinh Aurélien, Duran Clara, Hamami Kamel, Afif Muriel, Bonnet Francine, Donay Jean-Luc, Lafaurie Matthieu, Chartier-Kastler Emmanuel
Infectious Disease Department, Raymond-Poincaré University Hospital, Paris Saclay University, Assistance Publique-Hôpitaux de Paris, Garches, France.
Pharmacy, Raymond-Poincaré University Hospital, Paris Saclay University, Assistance Publique-Hôpitaux de Paris, Garches, France.
Open Forum Infect Dis. 2022 May 12;9(7):ofac245. doi: 10.1093/ofid/ofac245. eCollection 2022 Jul.
Urinary tract infections (UTIs) are the most common bacterial infections in patients with neurogenic lower urinary tract dysfunction. Antibiotic options for prophylaxis or curative treatment in case of recurrent UTIs, especially due to multidrug-resistant organisms (MDRO), are scarce. We present the case of a 72-year-old man with neurogenic lower urinary tract dysfunction and history of frequent recurrent UTIs due to multiple MDROs who was successfully treated with hyaluronic acid (HA) and chondroitin sulfate (CS) bladder instillations. We also provide a literature review on the efficacy of HA-CS intravesical instillations for prevention of UTI among this population.
尿路感染（UTIs）是神经源性下尿路功能障碍患者中最常见的细菌感染。对于复发性UTIs，尤其是由多重耐药菌（MDRO）引起的，预防或治疗性的抗生素选择很少。我们报告了一例72岁男性患者，患有神经源性下尿路功能障碍，因多种MDRO导致频繁复发性UTIs，经透明质酸（HA）和硫酸软骨素（CS）膀胱灌注成功治疗。我们还提供了一篇关于HA-CS膀胱内灌注对该人群预防UTI疗效的文献综述。
