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低头综合征的外科治疗:一项系统评价。

Surgical management of dropped head syndrome: A systematic review.

作者信息

Cavagnaro María José, Orenday-Barraza José Manuel, Hussein Amna, Avila Mauricio J, Farhadi Dara, Alvarez Reyes Angelica, Bauer Isabel L, Khan Naushaba, Baaj Ali A

机构信息

Department of Neurosurgery, University of Arizona, Phoenix, United States.

Department of Neurosurgery, University of Arizona College of Medicine, Phoenix, United States.

出版信息

Surg Neurol Int. 2022 Jun 17;13:255. doi: 10.25259/SNI_456_2022. eCollection 2022.

Abstract

BACKGROUND

Dropped head syndrome (DHS) is uncommon and involves severe weakness of neck-extensor muscles resulting in a progressive reducible cervical kyphosis. The first-line management consists of medical treatment targeted at diagnosing underlying pathologies. However, the surgical management of DHS has not been well studied.

METHODS

Here, we systematically reviewed the PubMed and Cochrane databases for DHS using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All relevant articles up to March 31, 2022, were analyzed. The patient had to be ≥18 years with DHS and had to have undergone surgery with outcomes data available. Outcomes measurements included neurological status, rate of failure (RF), horizontal gaze, and complications.

RESULTS

A total of 22 articles selected for this study identified 54 patients who averaged 68.9 years of age. Cervical arthrodesis without thoracic extension was performed in seven patients with a RF of 71%. Cervicothoracic arthrodesis was performed in 46 patients with an RF of 13%. The most chosen upper level of fusion was C2 in 63% of cases, and the occiput was included only in 13% of patients. All patients neurologically stabilized or improved, while 75% of undergoing anterior procedures exhibited postoperative dysphagia and/or airway-related complications.

CONCLUSION

The early surgery for patients with DHS who demonstrate neurological compromise or progressive deformity is safe and effective and leads to excellent outcomes.

摘要

背景

垂头综合征(DHS)并不常见,涉及颈部伸肌严重无力,导致进行性可复性颈椎后凸。一线治疗包括针对潜在病理诊断的医学治疗。然而,DHS的手术治疗尚未得到充分研究。

方法

在此,我们按照系统评价和Meta分析的首选报告项目指南,系统检索了PubMed和Cochrane数据库中有关DHS的文献。分析了截至2022年3月31日的所有相关文章。患者必须年满18岁且患有DHS,并且必须接受过手术且有可用的结局数据。结局指标包括神经状态、失败率(RF)、水平凝视和并发症。

结果

本研究共纳入22篇文章,确定了54例患者,平均年龄68.9岁。7例患者进行了不包括胸椎延长的颈椎融合术,失败率为71%。46例患者进行了颈胸融合术,失败率为13%。63%的病例中最常选择的融合上位水平为C2,仅13%的患者包括枕骨。所有患者神经功能均稳定或改善,而75%接受前路手术的患者出现术后吞咽困难和/或气道相关并发症。

结论

对于出现神经功能损害或进行性畸形的DHS患者,早期手术安全有效,可带来良好的结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a546/9282730/eb238272430b/SNI-13-255-g001.jpg

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