Nakashima Y, Esashi T
J Nutr Sci Vitaminol (Tokyo). 1986 Dec;32(6):569-79. doi: 10.3177/jnsv.32.569.
To study the relationship between age-related stimulation of sympathetic nervous activity and vitamin E, excretion of urinary catecholamine and the contents of organ catecholamine were measured in rats receiving a vitamin E-deficient or control diet for 95 weeks. Rats exhibited about 95% hemolysis after 4 weeks on the vitamin E-deficient diet and this value remained the same for 95 weeks. alpha-Tocopherol in plasma was not detectable in the deficient diet-fed rats, and lipid peroxide concentrations in the plasma, liver and adrenal glands of rats receiving the vitamin E-deficient diet for 95 weeks were 3- to 30-fold higher than those of control rats. Urinary excretion of catecholamine (norepinephrine (NE), epinephrine (E) and dopamine (DA] increased with age. Excretion of NE in 24-h urine of rats receiving the vitamin E-deficient diet for 50 and 95 weeks was 2- to 3-fold higher than that of control rats, although no significant difference was observed at week 12. Contents of NE and E in the adrenal glands and of NE in the heart from the deficient rats were significantly lower than those of control rats at week 95. These results suggest that sympathetic nervous activity is enhanced in aged rats and that the sympathetic nervous activity in vitamin E-deficient rats is greater than in control rats.
为研究与年龄相关的交感神经活动刺激与维生素E之间的关系，对食用维生素E缺乏或对照饮食95周的大鼠测量尿儿茶酚胺排泄量及器官儿茶酚胺含量。在维生素E缺乏饮食喂养4周后，大鼠出现约95%的溶血，此值在95周内保持不变。在喂食缺乏饮食的大鼠中，血浆中的α-生育酚无法检测到，接受维生素E缺乏饮食95周的大鼠血浆、肝脏和肾上腺中的脂质过氧化物浓度比对照大鼠高3至30倍。儿茶酚胺（去甲肾上腺素（NE）、肾上腺素（E）和多巴胺（DA））的尿排泄量随年龄增加。接受维生素E缺乏饮食50周和95周的大鼠24小时尿中NE排泄量比对照大鼠高2至3倍，尽管在第12周未观察到显著差异。在第95周时，缺乏维生素E的大鼠肾上腺中NE和E的含量以及心脏中NE的含量显著低于对照大鼠。这些结果表明，老年大鼠的交感神经活动增强，且维生素E缺乏大鼠的交感神经活动大于对照大鼠。
