Nakashima Y, Esashi T
Seitoku Gakuen Junior College for Women, Chiba, Japan.
J Nutr Sci Vitaminol (Tokyo). 1987 Oct;33(5):321-32. doi: 10.3177/jnsv.33.321.
This study was undertaken to examine whether some stressful conditions affected urinary output of catecholamine of 3- and 18-month-old vitamin E-deficient rats and control rats. Basal levels of urinary norepinephrine (NE) and epinephrine (E) excretion of aged vitamin E-deficient rats was 2- to 3-fold higher than those of control rats. In both groups of young rats, cold exposure, administration of insulin, and immobilization stress provoked a marked increase in urinary output of NE, E, NE and E, respectively. However, the urinary catecholamine responses to these stresses were markedly diminished in aged rats. No significant changes were observed in excretion of catecholamine during these stresses in aged rats receiving vitamin E-deficient diet. Therefore, these results suggested that the responses of sympathetic nervous activity to these stresses were significantly lowered in the chronic vitamin E-deficient rats compared to control rats.
本研究旨在探讨某些应激条件是否会影响3月龄和18月龄维生素E缺乏大鼠及对照大鼠的儿茶酚胺尿量。老年维生素E缺乏大鼠尿去甲肾上腺素（NE）和肾上腺素（E）排泄的基础水平比对照大鼠高2至3倍。在两组幼鼠中，冷暴露、注射胰岛素和固定应激分别引起NE、E、NE和E尿量的显著增加。然而，老年大鼠对这些应激的尿儿茶酚胺反应明显减弱。在接受维生素E缺乏饮食的老年大鼠中，这些应激期间儿茶酚胺排泄未观察到显著变化。因此，这些结果表明，与对照大鼠相比，慢性维生素E缺乏大鼠交感神经活动对这些应激的反应显著降低。
