Department of Endocrinology, The Fifth Medical Center of Chinese PLA Hospital, Beijing, China.
Department of Day Clinic, The Fifth Medical Center of Chinese PLA Hospital, Beijing, China.
Comput Math Methods Med. 2022 Jul 9;2022:1776875. doi: 10.1155/2022/1776875. eCollection 2022.
Fatty liver disease (FLD) is strongly linked to the occurrence of type 2 diabetes mellitus (T2DM). Insulin resistance (IR) is linked to smoking. Our study's purpose was to see how smoking and fatty liver accompanied affected the development of T2DM in the past.
We collected data from 15,464 Japanese adults aged 18 to 79 years who took part in the NAGALA research, and our team utilized a Cox proportion risk model to look at the combination effect of FLD and smoking status on the incidence of T2DM. Participants were separated into three categories: nonsmokers, ex-smokers, and current smokers. An abdominal ultrasound was used to diagnose FLD.
384 subjects had T2DM after a median follow-up of 5.4 years. In comparison to the other groups, current FLD smokers had a greater chance of developing T2DM. Ex-smokers and present FLD smokers, on the other hand, had no significant difference in their likelihood of acquiring T2DM. When compared to ex-smokers and nonsmokers without FLD, current smokers with FLD had a considerably greater chance of acquiring T2DM. Furthermore, the risk of T2DM among nonsmokers, ex-smokers with FLD, and current smokers without FLD was not statistically significant.
In order to prevent the progression of T2DM, we should recognize that smoking status may vary in FLD.
脂肪肝疾病（FLD）与 2 型糖尿病（T2DM）的发生密切相关。胰岛素抵抗（IR）与吸烟有关。我们的研究目的是观察过去吸烟和脂肪肝对 T2DM 发展的影响。
我们收集了参加 NAGALA 研究的 15464 名 18 至 79 岁的日本成年人的数据，我们的团队利用 Cox 比例风险模型观察 FLD 和吸烟状况对 T2DM 发生率的联合效应。参与者分为三组：不吸烟者、戒烟者和现吸烟者。使用腹部超声诊断 FLD。
在中位随访 5.4 年后，384 名受试者患有 T2DM。与其他组相比，当前 FLD 吸烟者患 T2DM 的可能性更大。然而，与戒烟者和现吸烟者相比，有 FLD 的现吸烟者患 T2DM 的可能性没有显著差异。与戒烟者和无 FLD 的非吸烟者相比，有 FLD 的现吸烟者患 T2DM 的可能性要大得多。此外，无 FLD 的非吸烟者、戒烟者和现吸烟者患 T2DM 的风险没有统计学意义。
为了预防 T2DM 的进展，我们应该认识到吸烟状况在 FLD 中可能会有所不同。
