Murray Henry W
Department of Medicine, Division of Infectious Diseases, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, United States of America.
IDCases. 2022 Jul 11;29:e01565. doi: 10.1016/j.idcr.2022.e01565. eCollection 2022.
In visceral leishmaniasis (as in all leishmanial infections), microscopic diagnosis is made by observing the intracellular amastigote form, complete with a kinetoplast, in aspirate smears or biopsied tissue. In the 2 clinically-ill patients described here, intracellular inclusions were demonstrated in a bone marrow aspirate or a colon tissue biopsy. Kinetoplasts associated with the inclusions were not identified in the marrow aspirate smear (although the patient was treated for visceral leishmaniasis), but were identified retrospectively in the colonic tissue (although the patient was treated for histoplasmosis). Both cases illustrate the importance to clinical consultants of microscopically observing (or not) an associated kinetoplast when faced with a tissue aspirate or biopsy specimen showing intracellular inclusions.
在内脏利什曼病（如同所有利什曼原虫感染一样）中，通过在抽吸涂片或活检组织中观察带有动基体的细胞内无鞭毛体形式进行显微镜诊断。在本文所述的2例临床患病患者中，在骨髓抽吸物或结肠组织活检中发现了细胞内包涵体。在骨髓抽吸涂片（尽管该患者接受了内脏利什曼病治疗）中未发现与包涵体相关的动基体，但在结肠组织中经回顾性检查发现了动基体（尽管该患者接受了组织胞浆菌病治疗）。这两个病例均说明了临床会诊医生在面对显示细胞内包涵体的组织抽吸物或活检标本时，通过显微镜观察（或未观察到）相关动基体的重要性。
