无症状HBsAg携带者中抗-HBc反应的多样性及其与其他免疫参数的相关性。
Diversity of the anti-HBc response and its correlations with other immunological parameters in asymptomatic HBsAg carriers.
作者信息
Lenkei R, Babeş V T, Steiner N, Mihăescu S
出版信息
Virologie. 1978 Jul-Sep;29(3):191-8.
PMID:358560
Abstract
The anti-HBc response was investigated by immunofluorescence in the sera of 109 asymptomatic HBsAg carriers. The results suggest the presence of at least two antigenic HBcAg determinants, possibly correlated with the replication phase. The subjects with intensive anti-HBc response showed immunological alterations consistent with the presence of active liver lesions and of hepatocellular membrane injury.
摘要
通过免疫荧光法对109例无症状HBsAg携带者血清中的抗-HBc反应进行了研究。结果提示至少存在两种抗原性HBcAg决定簇，可能与复制阶段相关。抗-HBc反应强烈的受试者表现出与活动性肝损伤和肝细胞细胞膜损伤存在相一致的免疫改变。
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