Department of Nutrition and Toxicology, Hangzhou Normal University School of Public Health, Hangzhou, 311121, China.
Zhejiang Provincial Center for Uterine Cancer Diagnosis and Therapy Research, The Affiliated Women's Hospital, Zhejiang University, Hangzhou, 310006, China.
Food Funct. 2022 Aug 15;13(16):8388-8398. doi: 10.1039/d1fo04333a.
: The preventive effects of probiotic supplementation against gestational diabetes mellitus (GDM) in pregnant women remain unclear. The objective of this review was to investigate the effect of probiotic supplementation on the profiles of glucose metabolism in pregnant women without diabetes. The published literature was retrieved and screened from PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang, and Cochrane Center Register of Controlled Trails up to April 1, 2021. Random controlled trials (RCTs) of probiotic supplementation on pregnant women without GDM were included. : 12 RCTs (2213 participants) were eligible for meta-analyses. Overall, probiotic supplementation significantly reduced GDM incidence (Risk Ratio (RR) = 0.62, 95% CI: 0.39-0.99), serum fasting blood glucose (FBG) (Mean Difference (MD) = -0.14 mmol L; 95% CI: -0.26 mmol L, -0.01 mmol L), insulin concentration (MD = -1.91 pmol L, 95% CI: -2.41 to -1.41), the homeostasis model assessment of insulin resistance (HOMA-IR) (MD = -0.32 mmol L; 95% CI: -0.42 mmol L, -0.22 mmol L), and Quantitative Insulin sensitivity Check Index (QUICKI) (MD = 0.02, 95% CI: 0.01,0.03) in pregnant women. Probiotic supplementation had no significant effects on the results of the oral glucose tolerance test (OGTT) (1 h OGTT, MD = -0.10, 95% CI: -0.30, 0.09; 2 h OGTT, MD = -0.06, 95% CI: -0.31, 0.20). : This meta-analysis suggested that probiotic supplementation may lead to an improvement in glycemic control and reduction of GDM incidence in pregnant women.
：益生菌补充剂对预防妊娠糖尿病（GDM）的作用在孕妇中尚不清楚。本综述的目的是研究益生菌补充剂对无糖尿病孕妇糖代谢特征的影响。检索了来自 PubMed、Embase、Web of Science、中国知网（CNKI）、万方和 Cochrane 中心对照试验注册库的已发表文献，截至 2021 年 4 月 1 日。纳入了无 GDM 的孕妇益生菌补充的随机对照试验（RCT）。：共有 12 项 RCT（2213 名参与者）符合荟萃分析的条件。总体而言，益生菌补充剂显著降低了 GDM 的发生率（风险比（RR）=0.62，95%可信区间：0.39-0.99）、血清空腹血糖（FBG）（均数差（MD）=-0.14mmol/L；95%可信区间：-0.26mmol/L，-0.01mmol/L）、胰岛素浓度（MD=-1.91pmol/L，95%可信区间：-2.41 至-1.41）、稳态模型评估的胰岛素抵抗（HOMA-IR）（MD=-0.32mmol/L；95%可信区间：-0.42mmol/L，-0.22mmol/L）和定量胰岛素敏感性检查指数（QUICKI）（MD=0.02，95%可信区间：0.01，0.03）。益生菌补充剂对口服葡萄糖耐量试验（OGTT）的结果没有显著影响（1hOGTT，MD=-0.10，95%可信区间：-0.30，0.09；2hOGTT，MD=-0.06，95%可信区间：-0.31，0.20）。：这项荟萃分析表明，益生菌补充剂可能导致孕妇血糖控制改善和 GDM 发生率降低。
