完全氘代

Radical deuteration.

作者信息

Li Nian, Li Yantao, Wu Xiaopeng, Zhu Chengjian, Xie Jin

机构信息

State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Green Catalysis Center, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China.

出版信息

Chem Soc Rev. 2022 Aug 1;51(15):6291-6306. doi: 10.1039/d1cs00907a.

DOI:10.1039/d1cs00907a

PMID:35856093

Abstract

Deuterated chemicals are becoming irreplaceable in pharmaceutical engineering, material science and synthetic chemistry. Many excellent reviews have discussed acid/base-dependent or metal-catalyzed deuteration reactions, but radical deuterations have been discussed less. With the development of radical chemistry, there has been a rapid growth in radical deuterium-labelling technology. Diverse mild, cheap and efficient strategies for deuterium atom installation have been reported, and this review summarizes the recent achievements of radical deuteration classified by the reaction types.

摘要

氘代化合物在药物工程、材料科学和合成化学中变得不可或缺。许多优秀的综述讨论了酸/碱依赖性或金属催化的氘代反应，但对自由基氘代反应的讨论较少。随着自由基化学的发展，自由基氘标记技术迅速发展。已经报道了多种温和、廉价且高效的引入氘原子的策略，本综述按反应类型总结了自由基氘代的最新成果。