National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Folia Med (Plovdiv). 2022 Jun 30;64(3):422-429. doi: 10.3897/folmed.64.e63624.
Mycoplasmagenitalium is an established cause of sexually transmitted infections in men and women. Current guidelines recommend azithromycin and moxifloxacin as first- and second-line treatment, respectively. However, azithromycin treatment failure has been increasingly reported. The aim of this study was to determine the efficacy of azithromycin and alternative antibiotic regimens in a prospective cohort of M.genitalium-positive patients, and macrolide resistance mutations associated with azithromycin failure.
生殖支原体是男性和女性性传播感染的既定病因。目前的指南分别推荐阿奇霉素和莫西沙星作为一线和二线治疗药物。然而，阿奇霉素治疗失败的情况越来越多。本研究旨在确定阿奇霉素和替代抗生素方案在生殖支原体阳性患者前瞻性队列中的疗效，以及与阿奇霉素失败相关的大环内酯类耐药突变。
