BRAF V600E 表达在原发性黑色素瘤及其与死亡的关系：一项基于人群的回顾性、横断面研究。
BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study.
机构信息
Dr. Harvey is from the Department of Dermatology, Mayo Clinic, Scottsdale, Arizona. Drs. Lehman, Chamberlain, Vachon, Markovic, and Brewer and Ms. Lohse are from the Mayo Clinic, Rochester, Minnesota. Drs. Lehman and Brewer are from the Department of Dermatology. Dr. Lehman also is from the Division of Anatomic Pathology. Ms. Lohse and Drs. Chamberlain and Vachon are from the Department of Health Sciences Research.
出版信息
Cutis. 2022 May;109(5):279-283. doi: 10.12788/cutis.0515.
Abstract
Approximately 50% of melanomas contain BRAF mutations; the effects on survival are unclear. We aimed to determine whether mutant BRAF expression in melanoma differs according to age, sex, and melanoma-specific survival. A total of 638 patients who resided in Olmsted County, Minnesota, with a first lifetime diagnosis of melanoma between 1970 and 2009 were identified from the Rochester Epidemiology Project (REP). Available tissue was analyzed for a BRAF V600E mutation with immunohistochemistry.
摘要
约 50%的黑色素瘤含有 BRAF 突变；其对生存的影响尚不清楚。我们旨在确定黑色素瘤中突变 BRAF 的表达是否因年龄、性别和黑色素瘤特异性生存而不同。总共确定了 638 名居住在明尼苏达州奥姆斯特德县的患者，他们在 1970 年至 2009 年间首次被诊断出患有黑色素瘤，并从罗切斯特流行病学项目 (REP) 中获得了这些患者的信息。对可用组织进行了 BRAF V600E 突变的免疫组织化学分析。
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Increasing Incidence of Melanoma in the Elderly: An Epidemiological Study in Olmsted County, Minnesota.老年人黑色素瘤发病率上升：明尼苏达州奥尔姆斯特德县的一项流行病学研究
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