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BRAF V600E 表达在原发性黑色素瘤及其与死亡的关系：一项基于人群的回顾性、横断面研究。

BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study.

机构信息

Dr. Harvey is from the Department of Dermatology, Mayo Clinic, Scottsdale, Arizona. Drs. Lehman, Chamberlain, Vachon, Markovic, and Brewer and Ms. Lohse are from the Mayo Clinic, Rochester, Minnesota. Drs. Lehman and Brewer are from the Department of Dermatology. Dr. Lehman also is from the Division of Anatomic Pathology. Ms. Lohse and Drs. Chamberlain and Vachon are from the Department of Health Sciences Research.

出版信息

Cutis. 2022 May;109(5):279-283. doi: 10.12788/cutis.0515.

DOI:10.12788/cutis.0515
PMID:35856752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9846848/
Abstract

Approximately 50% of melanomas contain BRAF mutations; the effects on survival are unclear. We aimed to determine whether mutant BRAF expression in melanoma differs according to age, sex, and melanoma-specific survival. A total of 638 patients who resided in Olmsted County, Minnesota, with a first lifetime diagnosis of melanoma between 1970 and 2009 were identified from the Rochester Epidemiology Project (REP). Available tissue was analyzed for a BRAF V600E mutation with immunohistochemistry.

摘要

约 50%的黑色素瘤含有 BRAF 突变；其对生存的影响尚不清楚。我们旨在确定黑色素瘤中突变 BRAF 的表达是否因年龄、性别和黑色素瘤特异性生存而不同。总共确定了 638 名居住在明尼苏达州奥姆斯特德县的患者，他们在 1970 年至 2009 年间首次被诊断出患有黑色素瘤，并从罗切斯特流行病学项目 (REP) 中获得了这些患者的信息。对可用组织进行了 BRAF V600E 突变的免疫组织化学分析。

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BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study.BRAF V600E 表达在原发性黑色素瘤及其与死亡的关系：一项基于人群的回顾性、横断面研究。
Cutis. 2022 May;109(5):279-283. doi: 10.12788/cutis.0515.
2
Association of BRAF V600E Status of Incident Melanoma and Risk for a Second Primary Malignancy: A Population-Based Study.BRAF V600E 状态与新发黑色素瘤及第二原发性恶性肿瘤风险的相关性：一项基于人群的研究。
Cutis. 2022 Sep;110(3):150-154. doi: 10.12788/cutis.0607.
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Reflectance confocal microscopy features of BRAF V600E mutated thin melanomas detected by immunohistochemistry.免疫组织化学检测到的BRAF V600E突变薄黑色素瘤的反射共聚焦显微镜特征。
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本文引用的文献

1
Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care.BRAF 和 NRAS 突变在黑色素瘤中的预后意义：一项来自常规护理的德国研究。
BMC Cancer. 2017 Aug 10;17(1):536. doi: 10.1186/s12885-017-3529-5.
2
Increasing Incidence of Melanoma in the Elderly: An Epidemiological Study in Olmsted County, Minnesota.老年人黑色素瘤发病率上升：明尼苏达州奥尔姆斯特德县的一项流行病学研究
Mayo Clin Proc. 2016 Nov;91(11):1555-1562. doi: 10.1016/j.mayocp.2016.06.028. Epub 2016 Sep 28.
3
BRAF mutations in conjunctival melanoma: investigation of incidence, clinicopathological features, prognosis and paired premalignant lesions.结膜黑色素瘤中的BRAF突变：发病率、临床病理特征、预后及配对的癌前病变研究
Acta Ophthalmol. 2016 Aug;94(5):463-70. doi: 10.1111/aos.13007. Epub 2016 Mar 24.
4
Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma.NRAS 和 BRAF 基因突变状态与高危原发性黑色素瘤患者的黑色素瘤特异性生存之间的关联。
JAMA Oncol. 2015 Jun;1(3):359-68. doi: 10.1001/jamaoncol.2015.0493.
5
Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma.BRAF 突变与原发性黑色素瘤临床病理特征的荟萃分析
J Am Acad Dermatol. 2015 Jun;72(6):1036-46.e2. doi: 10.1016/j.jaad.2015.02.1113. Epub 2015 Mar 25.
6
The role of BRAF mutations in primary melanoma growth rate and survival.BRAF 突变在原发性黑色素瘤生长速度和存活率中的作用。
Br J Dermatol. 2015 Jul;173(1):76-82. doi: 10.1111/bjd.13756. Epub 2015 Jun 13.
7
Increasing incidence of melanoma among middle-aged adults: an epidemiologic study in Olmsted County, Minnesota.中年人群中黑色素瘤发病率的上升：明尼苏达州奥姆斯特德县的一项流行病学研究。
Mayo Clin Proc. 2014 Jan;89(1):52-9. doi: 10.1016/j.mayocp.2013.09.014.
8
Novel approaches in melanoma prevention and therapy.黑色素瘤预防与治疗的新方法。
Cancer Treat Res. 2014;159:443-55. doi: 10.1007/978-3-642-38007-5_25.
9
History of the Rochester Epidemiology Project: half a century of medical records linkage in a US population.罗切斯特流行病学项目历史：半个世纪以来美国人群的医疗记录链接
Mayo Clin Proc. 2012 Dec;87(12):1202-13. doi: 10.1016/j.mayocp.2012.08.012. Epub 2012 Nov 28.
10
Increasing incidence of melanoma among young adults: an epidemiological study in Olmsted County, Minnesota.年轻人中黑色素瘤发病率上升：明尼苏达州奥姆斯特德县的一项流行病学研究。
Mayo Clin Proc. 2012 Apr;87(4):328-34. doi: 10.1016/j.mayocp.2012.01.010.