Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California, USA.
Gerontology Program, California State University, Sacramento, Sacramento, California, USA.
Biopreserv Biobank. 2023 Jun;21(3):282-287. doi: 10.1089/bio.2022.0022. Epub 2022 Jul 19.
In 1984, the National Institute on Aging developed the Alzheimer's disease centers program. The main goal of these centers is to advance the understanding of Alzheimer's disease and related dementias (ADRD) through comprehensive patient evaluations and cutting-edge research in pathology, laboratory medicine, education, and scientific discovery. The neuropathology core of the Alzheimer's Disease Research Centers (ADRCs) collects postmortem brain tissue from consented donors ranging from cognitively normal individuals to those with late-stage dementia, whose samples and data can be shared around the world to further advance knowledge, diagnosis, and to eventually find cures for ADRD. Although recommended guidelines for biorepositories exist, we aimed to understand the current practices within neuropathology cores across the ADRCs. A survey was developed that focused on information related to sample processing methods, biospecimen requests, financial costs related to the repository, and data management. This survey was distributed to 28 current and former ADRC neuropathology cores. The survey obtained a response rate of 82% (23/28). Although most centers were consistent in responses related to sample processing and storage, they varied widely in processes by which neuropathological samples are shared and cost recovery mechanisms. The results of this survey provide benchmark data on practices within neuropathology cores across ADRCs and the overlap with biorepository best practices. Future studies focused on understanding factors that may influence current practices (such as available funds and personnel) are need to aid in minimizing barriers to optimally follow best practices. Sharing these data among ADRCs will allow for improvement in workflows and working toward cures for ADRD.
1984 年，美国国家老龄化研究所制定了阿尔茨海默病中心计划。这些中心的主要目标是通过全面的患者评估和病理学、实验室医学、教育和科学发现方面的前沿研究，推进对阿尔茨海默病和相关痴呆症（ADRD）的理解。阿尔茨海默病研究中心（ADRC）的神经病理学核心从认知正常的个体到晚期痴呆症患者的同意捐赠者中收集死后脑组织，其样本和数据可以在全球范围内共享，以进一步推进知识、诊断，并最终找到治疗 ADRD 的方法。尽管存在推荐的生物库指南，但我们旨在了解 ADRC 中神经病理学核心的当前实践。制定了一项侧重于样本处理方法、生物标本请求、与存储库相关的财务成本以及数据管理相关信息的调查。该调查分发给 28 个当前和前任 ADRC 神经病理学核心。该调查的回复率为 82%（23/28）。尽管大多数中心在样本处理和存储相关的回复上保持一致，但在神经病理样本共享的过程和成本回收机制上存在很大差异。该调查的结果提供了 ADRC 神经病理学核心内实践的基准数据，以及与生物库最佳实践的重叠。未来的研究侧重于了解可能影响当前实践的因素（例如可用资金和人员），以帮助尽量减少最佳实践的障碍。在 ADRC 之间共享这些数据将改善工作流程，并为治疗 ADRD 做出努力。
