Tao Jianxin, Zhu Lei, Yakoub Mina, Reißfelder Christoph, Loges Sonja, Schölch Sebastian
JCCU Translational Surgical Oncology (A430), German Cancer Research Center (DKFZ), Heidelberg, Germany.
DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.
Cancer Res. 2022 Aug 3;82(15):2661-2671. doi: 10.1158/0008-5472.CAN-22-0906.
Circulating tumor cells are the cellular mediators of distant metastasis in solid malignancies. Their metastatic potential can be augmented by clustering with other tumor cells or nonmalignant cells, forming circulating tumor microemboli (CTM). Cell-cell interactions are key regulators within CTM that convey enhanced metastatic properties, including improved cell survival, immune evasion, and effective extravasation into distant organs. However, the cellular and molecular mechanism of CTM formation, as well as the biology of interactions between tumor cells and immune cells, platelets, and stromal cells in the circulation, remains to be determined. Here, we review the current literature on cell-cell interactions in homotypic and heterotypic CTM and provide perspectives on therapeutic strategies to attenuate CTM-mediated metastasis by targeting cell-cell interactions.
循环肿瘤细胞是实体恶性肿瘤远处转移的细胞介质。它们的转移潜能可通过与其他肿瘤细胞或非恶性细胞聚集而增强，形成循环肿瘤微栓子（CTM）。细胞间相互作用是CTM内的关键调节因子，可传递增强的转移特性，包括提高细胞存活率、免疫逃逸以及有效外渗至远处器官。然而，CTM形成的细胞和分子机制，以及循环中肿瘤细胞与免疫细胞、血小板和基质细胞之间相互作用的生物学特性仍有待确定。在此，我们综述了关于同型和异型CTM中细胞间相互作用的当前文献，并针对通过靶向细胞间相互作用来减弱CTM介导的转移的治疗策略提出了观点。
