Wu Sijia, Zhang Jiajin, Wang Yanfei, Qin Xinyu, Zhang Zhaocan, Lu Zhennan, Kim Pora, Zhou Xiaobo, Huang Liyu
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, PR China.
School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Nucleic Acids Res. 2025 Jan 6;53(D1):D1427-D1434. doi: 10.1093/nar/gkae916.
Cancer metastasis, the process by which tumour cells migrate and colonize distant organs from a primary site, is responsible for the majority of cancer-related deaths. Understanding the cellular and molecular mechanisms underlying this complex process is essential for developing effective metastasis prevention and therapy strategies. To this end, we systematically analysed 1786 bulk tissue samples from 13 cancer types, 988 463 single cells from 17 cancer types, and 40 252 spots from 45 spatial slides across 10 cancer types. The results of these analyses are compiled in the metsDB database, accessible at https://relab.xidian.edu.cn/metsDB/. This database provides insights into alterations in cell constitutions, cell relationships, biological pathways, molecular biomarkers, and drug responses during cancer metastasis at bulk, single-cell, and spatial levels. Users can perform cell or gene searches to obtain multi-view and multi-scale metastasis-related data. This comprehensive resource is invaluable for understanding the metastasis process and for designing molecular therapies.
癌症转移是肿瘤细胞从原发部位迁移并定植到远处器官的过程，它导致了大多数与癌症相关的死亡。了解这一复杂过程背后的细胞和分子机制对于制定有效的转移预防和治疗策略至关重要。为此，我们系统分析了来自13种癌症类型的1786份大块组织样本、来自17种癌症类型的988463个单细胞以及来自10种癌症类型的45张空间玻片上的40252个斑点。这些分析结果汇总在metsDB数据库中，可通过https://relab.xidian.edu.cn/metsDB/访问。该数据库提供了在大块、单细胞和空间水平上癌症转移过程中细胞组成、细胞关系、生物途径、分子生物标志物和药物反应变化的见解。用户可以进行细胞或基因搜索，以获取多视角和多尺度的转移相关数据。这一综合资源对于理解转移过程和设计分子疗法具有重要价值。
