• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

双羟甲基四羟甲基硫酸磷对妊娠家兔维生素 A 体内平衡的破坏作用。

Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits.

机构信息

Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.

Department of Gastroenterology and Hepatology, University of Groningen, University Medi-cal Center Groningen, Groningen, The Netherlands.

出版信息

J Appl Toxicol. 2022 Dec;42(12):1921-1936. doi: 10.1002/jat.4364. Epub 2022 Aug 24.

DOI:10.1002/jat.4364
PMID:35857281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9804500/
Abstract

The biocide tetrakis(hydroxymethyl)phosphonium sulphate (THPS) and other members of the tetrakis(hydroxymethyl) phosphonium salts (THPX) family are associated with liver toxicity in several mammalian species and teratogenicity in rabbits. Malformations include skeletal changes and abnormalities in eye development and are very similar to those seen with vitamin A deficiency or excess. For this reason, it was hypothesized that teratogenicity of THPS(X) might be attributed to disturbances in retinol availability and/or metabolism as a result of maternal toxicity, for example, either due to insufficient dietary intake by the mothers or due to liver toxicity. Therefore, in the present study, liver toxicity and vitamin A homeostasis were studied in pregnant rabbits that were exposed to 13.8 or 46.0 mg/kg THPS during organogenesis and in precision-cut liver slices of rats and rabbits exposed to 0-70 μM THPS. Results show that in vivo exposure to THPS leads to a marked reduction of food intake, increased plasma concentrations of γ-glutamytransferase, degenerative changes in the liver and to changes in retinoid content in liver and plasma in the rabbits during organogenesis. In addition, THPS, both in vivo and ex vivo, caused a change in expression of proteins related to vitamin A metabolism and transport. Together, these observations could explain the birth defects observed in earlier teratogenicity studies.

摘要

季戊四醇四羟甲基硫酸磷（THPS）和其他四羟甲基鏻盐（THPX）家族成员与几种哺乳动物的肝毒性和兔的致畸性有关。畸形包括骨骼变化和眼部发育异常，与维生素 A 缺乏或过量引起的畸形非常相似。因此，有人假设 THPS（X）的致畸性可能归因于母体毒性引起的视黄醇可用性和/或代谢紊乱，例如，由于母亲的饮食摄入不足或由于肝毒性。因此，在本研究中，研究了在器官发生期间暴露于 13.8 或 46.0mg/kg THPS 的怀孕兔子以及暴露于 0-70μM THPS 的大鼠和兔子的精密肝切片中的肝毒性和维生素 A 动态平衡。结果表明，体内暴露于 THPS 导致兔子在器官发生期间食物摄入量明显减少，血浆γ-谷氨酰转移酶浓度升高，肝脏发生退行性变化，以及肝脏和血浆中视黄醇含量发生变化。此外，THPS 无论是体内还是体外，都会导致与维生素 A 代谢和转运相关的蛋白质表达发生变化。这些观察结果可以解释早期致畸性研究中观察到的出生缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/3624d590a3d5/JAT-42-1921-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/0ae9b9a53d3d/JAT-42-1921-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/671d3884e7a8/JAT-42-1921-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/acc09f011b40/JAT-42-1921-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/a875d6f9f2b6/JAT-42-1921-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/00601b7b597f/JAT-42-1921-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/e450c3d2a73d/JAT-42-1921-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/08fc74642a94/JAT-42-1921-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/067ce2988199/JAT-42-1921-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/3624d590a3d5/JAT-42-1921-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/0ae9b9a53d3d/JAT-42-1921-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/671d3884e7a8/JAT-42-1921-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/acc09f011b40/JAT-42-1921-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/a875d6f9f2b6/JAT-42-1921-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/00601b7b597f/JAT-42-1921-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/e450c3d2a73d/JAT-42-1921-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/08fc74642a94/JAT-42-1921-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/067ce2988199/JAT-42-1921-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96c/9804500/3624d590a3d5/JAT-42-1921-g005.jpg

相似文献

1
Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits.双羟甲基四羟甲基硫酸磷对妊娠家兔维生素 A 体内平衡的破坏作用。
J Appl Toxicol. 2022 Dec;42(12):1921-1936. doi: 10.1002/jat.4364. Epub 2022 Aug 24.
2
NTP Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CAS No. 55566-30-8) and Tetrakis(hydroxymethyl)phosphonium chloride (THPC) (CAS No. 124-64-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies).四羟甲基硫酸鏻（CAS编号：55566-30-8）和四羟甲基氯化鏻（CAS编号：124-64-1）在F344/N大鼠和B6C3F1小鼠中的NTP毒理学和致癌性研究（灌胃研究）
Natl Toxicol Program Tech Rep Ser. 1987 Feb;296:1-290.
3
Effect of long term application of tetrakis(hydroxymethyl)phosphonium sulfate (THPS) in a light oil-producing oilfield.硫酸四羟甲基鏻（THPS）在轻质油生产油田中的长期应用效果
Biofouling. 2018 Jul;34(6):605-617. doi: 10.1080/08927014.2018.1476500. Epub 2018 Aug 27.
4
Effects of tetrakis (hydroxymethyl) phosphonium sulfate pretreatment on characteristics of sewage sludge.四羟甲基硫酸鏻预处理对污水污泥特性的影响。
J Environ Sci (China). 2019 Apr;78:174-182. doi: 10.1016/j.jes.2018.09.013. Epub 2018 Sep 26.
5
Mitigation of EH36 ship steel biocorrosion using an antimicrobial peptide as a green biocide enhancer.使用抗菌肽作为绿色杀生剂增效剂来减轻 EH36 船用钢的生物腐蚀。
Bioelectrochemistry. 2023 Dec;154:108526. doi: 10.1016/j.bioelechem.2023.108526. Epub 2023 Jul 21.
6
Inadequate dosing of THPS treatment increases microbially influenced corrosion of pipeline steel by inducing biofilm growth of Desulfovibrio hontreensis SY-21.THPS 处理剂投加量不足会通过诱导脱硫弧菌 SY-21 生物膜的生长，增加管道钢的微生物影响腐蚀。
Bioelectrochemistry. 2022 Jun;145:108048. doi: 10.1016/j.bioelechem.2021.108048. Epub 2022 Jan 4.
7
Teratogenicity, tissue distribution, and metabolism of the retro-retinoids, 14-hydroxy-4,14-retro-retinol and anhydroretinol, in the C57BL/6J mouse.反式视黄醇（14-羟基-4,14-反式视黄醇和脱水视黄醇）在C57BL/6J小鼠中的致畸性、组织分布及代谢
Toxicol Appl Pharmacol. 2000 Feb 15;163(1):38-49. doi: 10.1006/taap.1999.8828.
8
Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis.卵磷脂：视黄醇酰基转移酶介导的视黄酯形成是小鼠胚胎发育过程中类视黄醇稳态的关键调节因子。
J Biol Chem. 2008 Feb 29;283(9):5611-21. doi: 10.1074/jbc.M708885200. Epub 2007 Dec 19.
9
A synergistic D-tyrosine and tetrakis hydroxymethyl phosphonium sulfate biocide combination for the mitigation of an SRB biofilm.协同的 D-酪氨酸和四羟甲基硫酸鏻生物杀灭剂组合，用于减轻硫酸盐还原菌生物膜。
World J Microbiol Biotechnol. 2012 Oct;28(10):3067-74. doi: 10.1007/s11274-012-1116-0. Epub 2012 Jun 27.
10
Food-grade D-limonene enhanced a green biocide in the mitigation of carbon steel biocorrosion by a mixed-culture biofilm consortium.食品级 D-苎烯增强了混合培养生物膜联合体对碳钢生物腐蚀的绿色杀菌剂的抑制效果。
Bioprocess Biosyst Eng. 2022 Apr;45(4):669-678. doi: 10.1007/s00449-021-02685-6. Epub 2022 Jan 8.

本文引用的文献

1
Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes.非酒精性脂肪性肝病（NAFLD）小鼠肝脏维生素 A 代谢受损导致肝细胞内维生素 A 蓄积。
Cell Mol Gastroenterol Hepatol. 2021;11(1):309-325.e3. doi: 10.1016/j.jcmgh.2020.07.006. Epub 2020 Jul 19.
2
Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity.乙醛抑制维 A 酸生物合成来介导酒精的致畸性。
Sci Rep. 2018 Jan 10;8(1):347. doi: 10.1038/s41598-017-18719-7.
3
Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD).
非酒精性脂肪性肝病 (NAFLD) 中维生素 A 代谢紊乱。
Nutrients. 2017 Dec 29;10(1):29. doi: 10.3390/nu10010029.
4
The interrelationship between bile acid and vitamin A homeostasis.胆汁酸与维生素 A 稳态的相互关系。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):496-512. doi: 10.1016/j.bbalip.2017.01.007. Epub 2017 Jan 19.
5
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.利用人类精密肝切片转录组学对胆汁淤积性和坏死性肝毒性物质进行分类
Chem Res Toxicol. 2016 Mar 21;29(3):342-51. doi: 10.1021/acs.chemrestox.5b00491. Epub 2016 Mar 9.
6
Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids.视黄酸代谢产物对CYP26A1的诱导作用：CYP26A1是消除活性类视黄醇的重要酶的证据。
Mol Pharmacol. 2015;87(3):430-41. doi: 10.1124/mol.114.096784. Epub 2014 Dec 9.
7
Retinol and retinyl esters: biochemistry and physiology.视黄醇和视黄醇酯：生物化学与生理学。
J Lipid Res. 2013 Jul;54(7):1731-43. doi: 10.1194/jlr.R037648. Epub 2013 Apr 26.
8
The adverse effects of alcohol on vitamin A metabolism.酒精对维生素 A 代谢的不良影响。
Nutrients. 2012 May;4(5):356-71. doi: 10.3390/nu4050356. Epub 2012 May 7.
9
Vitamin A in reproduction and development.维生素 A 在生殖和发育中的作用。
Nutrients. 2011 Apr;3(4):385-428. doi: 10.3390/nu3040385. Epub 2011 Mar 29.
10
Species- and strain-dependent teratogenicity of methanol in rabbits and mice.甲醇在兔和鼠中具有种属和品系依赖性的致畸性。
Reprod Toxicol. 2011 Jan;31(1):50-8. doi: 10.1016/j.reprotox.2010.09.014. Epub 2010 Oct 16.