Çelik Muhammet Cihat, Karayiğit Orhan, Ozkan Can, Dolu Abdullah Kadir, Kalçık Macit
Department of Cardiology, 485536Hitit University Erol Olçok Education and Research Hospital, Corum, Turkey.
Department of Cardiology, 233009Yozgat City Hospital, Yozgat, Turkey.
Angiology. 2023 Apr;74(4):387-394. doi: 10.1177/00033197221115562. Epub 2022 Jul 20.
This study aimed to evaluate the relationship between no-reflow phenomenon and systemic inflammation index (SII) and to compare the predictive capacity of SII together with the neutrophil-lymphocyte ratio (NLR), and the platelet-lymphocyte ratio (PLR) in patients with ST-elevation myocardial infarction (STEMI). A total of 785 patients were included. The thrombolysis in myocardial infarction (TIMI) flow degree has been used to describe the no-reflow phenomenon. The study population was divided into two groups regarding the presence of no-reflow phenomenon including 110 patients with no-reflow (TIMI frame count 0-2) and 675 patients without no-reflow (TIMI frame count 3). The NLR [6.6 (4.6-11.6) vs 3.2 (2.0-5.3); < .001], PLR [175 (121.3-220) vs 102.6 (76.1-150.1); < .001] and SII [1921(1225-2906) vs 738.5 (450.5-1293); < .001] were significantly higher in the no-reflow group. High NLR (OR: 1.078, 95%CI: 1.027-1.397; = .021), PLR (OR: 1.009, 95%CI: 1.003-1.021; = .041) and SII (OR: 1.216, 95%CI: 1.106-1.942; = .004) were found to be independently associated with no-reflow phenomenon. The comparison of the receiver-operating characteristic curves showed that area under the curve of SII was greater than that of NLR (.789 vs .766, = .007) and PLR (.789 vs .759, = .048). SII levels may predict no-reflow phenomenon better than NLR and PLR.
本研究旨在评估无复流现象与全身炎症指标（SII）之间的关系，并比较SII与中性粒细胞-淋巴细胞比值（NLR）及血小板-淋巴细胞比值（PLR）对ST段抬高型心肌梗死（STEMI）患者无复流现象的预测能力。共纳入785例患者。采用心肌梗死溶栓（TIMI）血流分级来描述无复流现象。根据有无无复流现象将研究人群分为两组，包括110例无复流患者（TIMI帧数0 - 2）和675例无无复流患者（TIMI帧数3）。无复流组的NLR[6.6（4.6 - 11.6）对3.2（2.0 - 5.3）；P <.001]、PLR[175（121.3 - 220）对102.6（76.1 - 150.1）；P <.001]和SII[1921（1225 - 2906）对738.5（450.5 - 1293）；P <.001]显著更高。发现高NLR（OR：1.078，95%CI：1.027 - 1.397；P = .021）、PLR（OR：1.009，95%CI：1.003 - 1.021；P = .041）和SII（OR：1.216，95%CI：1.106 - 1.942；P = .004）与无复流现象独立相关。受试者工作特征曲线比较显示，SII的曲线下面积大于NLR（.789对.766，P = .007）和PLR（.789对.759，P = .048）。SII水平对无复流现象的预测可能优于NLR和PLR。
