Ozbay Mustafa B, Degirmen Serhat, Gullu Aysenur, Nriagu Bede N, Omer Mohammed, Özen Yasin, Yayla Cagri
Internal Medicine, Penn Medicine Princeton Medical Center, Plainsboro, USA.
Internal Medicine, New York Medical College, Metropolitan Hospital Center, New York, USA.
Cureus. 2025 Apr 4;17(4):e81712. doi: 10.7759/cureus.81712. eCollection 2025 Apr.
The no-reflow phenomenon (NR) following percutaneous coronary intervention (PCI) is an unpredictable complication linked to increased in-hospital mortality and adverse cardiovascular outcomes. Reliable predictors of NR remain unclear. This systematic review and meta-analysis aimed to evaluate the association between serum uric acid to albumin ratio (UAR) and NR development after PCI. A comprehensive search of MEDLINE, Cochrane, and EMBASE databases identified observational studies assessing this relationship. Studies that provided multivariate regression analyses to determine whether UAR is an independent predictor of NR were included, and pooled odds ratios (OR) were calculated using random effects models. Three studies with a total of 2,199 patients were included. The pooled analysis demonstrated a significant association between higher UAR and an increased risk of NR (OR: 3.04; 95% CI: 2.26-4.10; p < 0.00001; I² = 0%). These findings indicate that a higher serum UAR is independently associated with NR development and may serve as a useful, easily measurable predictor in clinical practice.
经皮冠状动脉介入治疗（PCI）后出现的无复流现象（NR）是一种不可预测的并发症，与住院死亡率增加和不良心血管结局相关。NR的可靠预测因素仍不明确。本系统评价和荟萃分析旨在评估血清尿酸与白蛋白比值（UAR）与PCI后NR发生之间的关联。对MEDLINE、Cochrane和EMBASE数据库进行全面检索，确定了评估这种关系的观察性研究。纳入提供多变量回归分析以确定UAR是否为NR独立预测因素的研究，并使用随机效应模型计算合并比值比（OR）。共纳入3项研究，总计2199例患者。汇总分析表明，较高的UAR与NR风险增加之间存在显著关联（OR：3.04；95%CI：2.26-4.10；p<0.00001；I²=0%）。这些发现表明，较高的血清UAR与NR发生独立相关，在临床实践中可能是一个有用的、易于测量的预测指标。
