Department of Pharmacology, Weill-Cornell Medical College, Cornell University, New York, New York, United States of America.
PLoS Biol. 2022 Jul 20;20(7):e3001720. doi: 10.1371/journal.pbio.3001720. eCollection 2022 Jul.
Nucleotide modifications can markedly influence mRNA processing and metabolism. New studies, one in PLOS Biology, show that approximately 130 yeast mRNAs contain dihydrouridine, a derivative of uridine. Functional studies show that dihydrouridine, in some cases, can affect mRNA splicing.
核苷酸修饰可以显著影响 mRNA 的加工和代谢。一项发表在《PLOS Biology》上的新研究表明，约 130 种酵母 mRNA 中含有二氢尿嘧啶核苷，这是尿嘧啶的一种衍生物。功能研究表明，在某些情况下，二氢尿嘧啶核苷会影响 mRNA 的剪接。
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