Department of Oral and Craniofacial Sciences, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA, United States of America.
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, United States of America.
PLoS One. 2022 Jul 20;17(7):e0271734. doi: 10.1371/journal.pone.0271734. eCollection 2022.
Mild curvature of the fifth finger (or clinodactyly) is a relatively common trait. While severe forms can cause functional impairment and are a feature of certain congenital syndromes, mild clinodactyly is considered a minor morphological variant. Despite exhibiting continuous variation, clinodactyly is rarely treated as a quantitative trait. Consequently, the degree of fifth finger curvature in the general population and the factors that impact this curvature are not well understood. In the present study, we measured fifth finger curvature in a sample of 1,295 U.S. adults and investigated the role of sex, age and body size. We found that clinodactyly exhibited a non-normal distribution. All participants displayed some degree of curvature, but it tended to be slight with an overall mean of 3.68 degrees (median: 3.58 degrees). In only 0.8% of cases did the curvature exceed the nominal 10-degree threshold for clinically meaningful clinodactyly. We did not find statically significant sex differences. Further, there was no meaningful relationship with height and only a weak positive relationship with age. We found that clinodactyly showed asymmetry; the curvature was greater on the left than on the right fifth finger (p < 2.2e-16), but this was not influenced by sex, age, or height. These results suggest the possibility that the kind of ubiquitous mild clinodactyly observed in the general population may be etiologically distinct from more rare and severe forms of the condition.
第五指(或弯指)轻度弯曲是一种相对常见的特征。虽然严重的弯曲形式会导致功能障碍,并且是某些先天性综合征的特征,但轻度弯指被认为是一种轻微的形态变异。尽管表现出连续变异,但弯指很少被视为数量性状。因此,一般人群中第五指弯曲的程度以及影响这种弯曲的因素尚不清楚。在本研究中,我们测量了 1295 名美国成年人样本中的第五指弯曲程度,并研究了性别、年龄和体型的作用。我们发现弯指呈非正态分布。所有参与者都表现出一定程度的弯曲,但通常很轻微,平均曲率为 3.68 度(中位数:3.58 度)。只有 0.8%的病例弯曲超过 10 度的临床意义弯指的名义阈值。我们没有发现统计学上显著的性别差异。此外,与身高没有有意义的关系,与年龄只有微弱的正相关。我们发现弯指存在不对称性;左侧第五指的弯曲程度大于右侧(p < 2.2e-16),但这不受性别、年龄或身高的影响。这些结果表明,在一般人群中观察到的普遍存在的轻度弯指可能在病因学上与更罕见和严重的形式不同。