Division of Systems Medicine, University of Dundee, Dundee, UK.
Department of Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Cardiology, Skåne University Hospital, Malmö, Sweden.
Cell Rep Med. 2022 Jul 19;3(7):100676. doi: 10.1016/j.xcrm.2022.100676.
The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] -0.14 [-0.06 to -0.02] p = 0.001, 0.15 [0.02-0.07] p = 0.001, and 0.20 [0.03-0.07] p < 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15-0.29] p < 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF.
影响高危个体动脉粥样硬化进程的因素仍知之甚少。在这里，我们采用血管成像、危险因素评估和生物标志物相结合的方法，在接受预防治疗的高危人群队列中（n=865），确定了与颈动脉疾病严重程度 3 年变化相关的因素。结果表明，颈动脉窦部内膜中层厚度（IMT）的变化最为显著。窦部 IMT 的进展与基线窦部 IMT、斑块灰度中位数（GSM）和血小板衍生生长因子（PDGF）的血浆水平独立相关（标准化β系数和 95%置信区间[CI]-0.14[-0.06 至-0.02]p=0.001，0.15[0.02-0.07]p=0.001 和 0.20[0.03-0.07]p<0.001）。PDGF 与斑块 GSM 相关（0.23[0.15-0.29]p<0.001）。这些观察结果通过显示进展主要发生在纤维斑块中，并与 PDGF 水平升高相关，为高危人群的动脉粥样硬化进程提供了深入了解。
