Chen Yuanyuan, Liu Ming, Lu Huayi, Zhang Yong, Luo Dan, Pan Hongbiao, Wan Chuan, Szentmáry Nóra, Shi Lei
Graduate School, Bengbu Medical College, Bengbu, China.
Department of Ophthalmology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Klin Monbl Augenheilkd. 2023 Oct;240(10):1151-1157. doi: 10.1055/a-1905-1998. Epub 2022 Jul 20.
To elucidate the influence of overnight wear of orthokeratology (OOK) lenses on the thickness of the tear lipid layer (LLT).
We conducted a retrospective cross-sectional study of children who visited The First Affiliated Hospital of USTC between July and September 2021. LLT and blinking dynamics were assessed. Diopters and corneal topography were also recorded.
The number of children enrolled in this program was 402 (804 eyes). One hundred and seventy-one children (342 eyes, 79 males and 92 females) aged 4 - 17 years (10.59 ± 2.54 years) who never wore OOK were included in the control group, while 231 children (462 eyes, 121 males and 110 females) aged 7 - 18 years (11.09 ± 2.24 years) who wore OOK for more than 1 week were included in the observation group. Compared to the control group with an LLT of 58.5 ± 18.19 nm, the OOK group exhibited a significant decrease in the LLT value to 54.42 ± 17.60 nm. In addition, the LLT in females was significantly thicker than that in males in both the control (male 54.78 ± 16.56 nm, female 61.70 ± 18.95 nm) and observation groups (male 51.88 ± 16.68 nm, female 57.21 ± 18.18 nm). It is worth noting that the influence of wearing OOK on the LLT value was only detected up to 18 months. Eighteen months later, there was almost no difference in LLT between the control and observation groups. We also noted that there was no change in LLT correlated to the surface regularity index/surface asymmetry index.
Wearing OOK can affect tear film LLT within the first 18 months after wear. More attention should be given to children wearing OOK for less than 18 months, especially males.
阐明角膜塑形术（OOK）镜片过夜佩戴对泪液脂质层（LLT）厚度的影响。
我们对2021年7月至9月期间就诊于中国科学技术大学附属第一医院的儿童进行了一项回顾性横断面研究。评估了LLT和眨眼动态。还记录了屈光度和角膜地形图。
本研究纳入的儿童数量为402名（804只眼）。对照组纳入171名4-17岁（10.59±2.54岁）从未佩戴过OOK的儿童（342只眼，男79名，女92名），观察组纳入231名7-18岁（11.09±2.24岁）佩戴OOK超过1周的儿童（462只眼，男121名，女110名）。与LLT为58.5±18.19nm的对照组相比，OOK组的LLT值显著降低至54.42±17.60nm。此外，对照组（男性54.78±16.56nm，女性61.70±18.95nm）和观察组（男性51.88±16.68nm，女性57.21±18.18nm）中女性的LLT均显著厚于男性。值得注意的是，佩戴OOK对LLT值的影响仅在18个月内被检测到。18个月后，对照组和观察组之间的LLT几乎没有差异。我们还注意到LLT的变化与表面规则性指数/表面不对称指数无关。
佩戴OOK在佩戴后的前18个月内会影响泪膜LLT。对于佩戴OOK不足18个月的儿童，尤其是男性，应给予更多关注。
