Yu Haozhe, Yuan Yifei, Wu Wenyu, Zeng Weizhen, Tong Louis, Zhang Yu, Feng Yun
Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Singapore Eye Research Institute, Singapore, Singapore.
Front Med (Lausanne). 2022 Feb 10;9:821106. doi: 10.3389/fmed.2022.821106. eCollection 2022.
Previous studies suggest that overnight orthokeratology (OOK) may be detrimental to tear function. We aimed to investigate the effect of OOK on lipid layer thickness (LLT), blink pattern, and meibomian gland and elucidate the relationship of these variables.
Thirty-seven participants who wore OOK lenses every night for at least 2 years and twenty-four healthy non-contact lens wearers (controls) were enrolled in this retrospective study. LipiView interferometry, blink pattern analysis, the ocular surface status, and morphology and function of the meibomian gland were determined.
The OOK group and healthy controls had similar LLT, blink patterns, ocular surface status, and the function of the meibomian gland. OOK participants demonstrated higher meiboscore in the lower eyelids ( < 0.05) but not in the upper eyelids. Within the OOK group, LLT was significantly impacted by the partial blink rate ( < 0.05) and the total score of the upper meibomian gland ( = 0.10).
Wearing OOK for 2 or more years increased lower eyelid meibomian gland dropout but did not have a reduction of LLT.
先前的研究表明，夜间角膜塑形术（OOK）可能对泪液功能有害。我们旨在研究OOK对脂质层厚度（LLT）、眨眼模式和睑板腺的影响，并阐明这些变量之间的关系。
本回顾性研究纳入了37名每晚佩戴OOK镜片至少2年的参与者和24名健康的非隐形眼镜佩戴者（对照组）。测定LipiView干涉测量法、眨眼模式分析、眼表状况以及睑板腺的形态和功能。
OOK组和健康对照组在LLT、眨眼模式、眼表状况和睑板腺功能方面相似。OOK参与者下眼睑的睑板腺评分较高（<0.05），但上眼睑则不然。在OOK组中，LLT受到部分眨眼率（<0.05）和上睑板腺总分（=0.10）的显著影响。
佩戴OOK两年或更长时间会增加下眼睑睑板腺的缺失，但不会降低LLT。
